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1、多奈哌齐治疗阿尔茨海默病的临床疗效研究吴娟(药学0802031310080203)【摘耍】冃的：验证多奈哌齐(Donepezil)治疗阿尔茨海默病(AD)的安全性及有效性。方法:对61例AD患者进行多奈哌齐和他克林(Tacrine)的多中心开放、对照治疗,其中多奈哌齐组33例(5mg/d),他克林组28例呼均100mg/d)；共治疗12周。应用简易精神状态检查(MMSE),FI常生活能力量表(ADL)评定临床疗效，用副反应量表(TESS)评定副反应。结果：多奈哌齐组治疗总有效率为69.70%,显效率为51.52%,他克林组分别为67.86%和46.43%,起效时间均在治疗
2、第四周末；两组间差异无显著性(x2分别二0.023和0.011)o多奈哌齐组和他克林组治疗前后MMSE评分及加分率，ADL评分及减分率的差异均无显著性(P>0.05)o多奈哌齐组的不良反应较他克林组显著少而轻，仅有6例病人存在轻度的恶心或胃纳减退。结论：多奈哌齐能有效治疗AD,且不良反应少而轻微。【关键词】阿尔茨海默病；多奈哌齐；他克林AcomparativestudyofdonepezilandAlzheimerdiseaseforClinicalresearch[abstract】ObjectiveVerifythattheDonepezilofmanywhatPai
3、nscuressafenatureandeffectivenessthatAhyouAlzheimerdisease(AD).MethodsButhavingmorewhatthemanycentersopenofneatandheforest(Tacrine)ofPayandcontrastto61exampleADpatientsiscured,amongthemmanywhatIZoosPay33examples(5mg/d),buthisLinZuof28examples(average1OOmg/cl)Weshouldcure12weeksaltogether.
4、Applyingthesimpleandeasystateofmindcheck(MMSE),theday-to-dayviabilityscalogram(ADL)ispassdjudgmentontheclinicalcurativeeffect,withtheby-reactionscalogram(TESS)evaluationby-reaction.ResultsManywhatQiZuPaicurethatbuttotalavailabilityfor51・52%,shisforestcomponentpartnotfor67.86%isallcuringth
5、earoundendwith46.43%,risestoimitatetimefor69.70%,sproduceeffectsrateThedifferencedoesnothavethesignificance(%2parts=0.023and0.011)betweentwoteams.ButmanywhatQiZuPaiandhisLinZuMMSEaroundcuringgivesamarkandaddsthedividesrate,andADLgivesamarktobereacheddifferencethatsubtractsthedividerateall
6、nottohavethesignificance(P>0.()5).ButhisLinZuisseldomnotableandlighttothemanywhatbadreactionsofIZuPay,andthenauseatingorstomachthatonlyhas6examplepatientsgentlytoexisttospendisreceivedtodrop.ConclusionsdonepezilisaneffectiveTreatmentMedicineAlzheimerdisease,withlesssideeffectsandbettersaf
7、etycomparedwithtacrine.【Keywords]Alzheimerdisease;Donepezil;tacrin痴呆症是老年期最常见的疾病。尽管只有1%的60岁老年人罹患此症，但却以每5岁成倍上升的状况累进，因此，如以85岁老年人作为统计对象，就会有30%〜45%老年人患此病。应当说明的是，阿尔茨海默病（AD,早老性痴呆）必然有痴呆表现，而痴呆表现并不等于ADoAD占所有痴呆病的50%〜60%,ffi美国1997年估计，约有400万人患有此病［1］,全国约有1500万AD患者。盐酸多奈哌齐是90年代末相继获
