肿瘤靶向治疗进展幻灯片1.ppt

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1、ONCOLOGYEpidemiologyAdaptedfromGreenleeRT,etal.CACancerJClin.2000:50;22.LeadingcausesofdeathPercentageofTotalDeaths,USHeartDiseasesCancerCerebrovascularDiseasesChronicObstructiveLungDiseasesAccidentsPneumonia&InfluenzaDiabetesMellitusSuicideHomicideHIVInfectionONCOLOGYEpidemiolo

2、gy1N.America369.9N.America277.52Australia/N.Z.312.7Australia/N.Z.254.03W.Europe294.8N.Europe234.54Japan270.9S.America*230.15N.Europe270.0W.Europe210.46E.Europe269.4Micronesia/205.2Polynesia7S.Europe256.0SouthernAfrica187.88S.America*255.1Melanesia185.69SouthernAfrica247.4S.Amer

3、ica†185.010EasternAsia‡235.7CentralAmerica180.111China171.7—591.4Incidence/Incidence/RankRegion100,000Region100,000*TemperateSouthAmerica.†TropicalSouthAmerica.‡OtherthanJapanorChina.AdaptedfromParkinDM,etal.CACancerJClin.1999;49:43.CancerincidencebyworldregionMalesFemalesLungC

4、ancerEpidemic—1915-1996CancerDeathRatesAge-Adjustedper100,000AmericanCancerSociety,SurveillanceResearch—Sources:USMortalityPublicUseData1960-1996;USMortalityVolumes1930-1959,NationalCenterforHealthStatistics,CDC,1999MalesFemales肿瘤医疗市场巨大WHO警告：今后20年将出现癌症的世界性流行到2010年全球发病人数将增加29.6-4

5、5.3%中国肿瘤年发病人数：240万/年每年需要治疗的肿瘤病人：500-800万100万人口城市每年需要治疗：5000--25000人综合医院肿瘤病人住院比率：10-35%国家县以上医院肿瘤每年公费医疗费214亿中国肝癌肺癌发病率及构成比发病率(10万)占肿瘤构成比例(%)肺癌61.0-100.641.4-59.6肝癌29.9-50.320.4-25.0合计90.9-159.961.8-84.6(中国肿瘤防治重点)1988-1992肿瘤治疗技术外科治疗化学治疗放射治疗中医中药免疫基因治疗其他疗法45%治愈贡献外科(20-22%)化学(5%)放射(18)

6、不开刀不放疗不化疗只杀癌细胞一个冬天里的神话街头广告挑战肿瘤专家肿瘤局部控制是治疗关键;局部控制失败导致复发转移DNADeliverytoCellsinPatient'sTissue基因治疗进展1.ReplacementandKnockoutGeneTherapyTheinductionofcelldeathorapoptosis.Theproductionofchangesincellgrowth,behavior,invasiveness,ormetastaticability.2.SuicideGeneTherapyalsoreferredtoa

7、stheuseofchemosensitizationandbystandereffectsimplexvirusthymidinekinasegene(HSV-tk)3.ImmunomodulatoryGeneTherapyinducecellularimmuneresponsestometastaticlesionsGenetherapy