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1、Pain,33(1988)87-10787ElsevierPA101188AperipheralmononeuropathyinratthatproducesdisordersofpainsensationlikethoseseeninmanGaryJ.BennettandY.-K.Xie1NeurobiologyandAnesthesiologyBranch,NationalInstituteofDentalResearch,NationalInstitutesofHealih,Bethesda,MD20892(U.S.A.)(R
2、eceived14August1987,revisionreceivedandaccepted2November1987)SummaryAperipheralmononeuropathywasproducedinadultratsbyplacinglooselyconstrictiveligaturesaroundthecommonsciaticnerve.Thepostoperativebehavioroftheseratsindicatedthathyperalgesia,allodyniaand,possibly,sponta
3、neouspain(ordysesthesia)wereproduced.Hyperalgesicresponsestonoxiousradiantheatwereevidentonthesecondpostoperativedayandlastedforover2months.Hyperalgesicresponsestochemogenicpainwerealsopresent.Thepresenceofallodyniawasinferredfromthenocifensiveresponsesevokedbystanding
4、onaninnocuous,chilledmetalfloororbyinnocuousmechanicalstimulation,andbytheratspersistenceinholdingthehindpawinaguardedposition.Thepresenceofspontaneouspainwassuggestedbyasuppressionofappetiteandbythefrequentoccurrenceofapparentlyspontaneousnocifensiveresponses.Theaffec
5、tedhindpawwasabnormallywarmorcoolinaboutone-thirdoftherats.Aboutone-halfoftheratsdevelopedgrosslyovergrownclawsontheaffectedside.Experimentswiththisanimalmodelmayadvanceourunderstandingoftheneuralmechanismsofneuropathicpaindisordersinhumans.Keywords:Painfulneuropathy;H
6、yperalgesia;Allodynia;CausalgiaIntroductionexperimentalanalysisofthepathologicprocessesinthenerveitself,butnoneofthemhasbeenWehaveaveryincompleteunderstandingofreportedtoproducedisordersofpainsensationtheneuropathogenesisofthedisordersofpainlikethosethataccompanyperiph
7、eralneuropathiessensationthatoccurwhenhumanperipheralinhumans.Ourinabilitytoproducethesesensorysomaticnervesaredamaged.Therearemanydisordersinlaboratoryanimalshasbeenamajoranimalmodelsofperipheralnerveinjuryduetoobstacletotheexperimentalanalysisoftheprob-trauma,disease
8、,metabolicdisorders,andtoxinslem.[lo].ThesemodelshavebeenofgreatvaluefortheThereis,however,ananimalmodelfortheconditi
