英国脑库的帕金森诊断标准(图片版)

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1、ParkinsoniansyndromeExclusioncriteriaParkinsoniansyndromeother

2、riteria.1992第一步先确定患者冇ParkinsoniansyndromeStep1BradykinesiaAtleastoneofthefollowingcriteria:Rigidity4-6HzresttremorPosturalinstabilitynotcausedbyprimaryvisual,vestibular,cerebellarorproprioceptivedysfunctionTable1ExclusioncriteriaforParkinson'sdisease117

3、]HistoryofrepeatedstrokeswithstepwiseprogressionofparkinsonianleaturesHistoryofrepeatedheadinjuryHistoryofdefiniteencephalitisOculogyriccrises(unlessdrug-induced)Neurolepticireatmenta(onsetofsymptomsSustainedremissionSupranucleargazepalsyCerebellarsigns

4、EarlysevereautonomicinvolvementEarlyseveredementiaBabinskisignPresenceofcerebraltumororcommunicatinghydrocephalusonCTscanNegativeresponseloanadequatedoseoflevodopaCT,computedtomography暗示可能是非典型Parkinsoniansyndrome的情形Table2Cluessuggestingatypicalparkinson

5、ismEarlyonsetof,orrapidlyprogressing,dementiaRapidlyprogressivecourseSupranucleargazepalsyUppermotorneuronsignsCerebellarsigns-dysmetria,ataxiaSevereurinaryincontinenceEarlysymptomaticposturalhypotensionStep3Atleastthreeofthefollowingsupportive(prospect

6、ive)criteria:UnilateralonsetResttremorProgressivedisorderPersistentasymmetryprimarilyaffectingsideofonsetExcellentresponse(70-100%)tolevodopaSeverelevodopainducedchorea(dyskinesia)Levodoparesponsefor5yearsormore「公锤隹Clinicalcourseof10yearsormore经由以上步骤，可以

7、诊断为ProbablePD若要诊断为DefinitePD,需要病理诊断!