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ID:47657661
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页数:7页
时间:2019-10-18
《临床评估五种膜式氧合器在不同温度下的跨膜压差【临床医学专业论文设计】》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、临床医学论文•临床评估五种膜式氧合器在不同温度下的跨膜压差作者:刘瑞芳,邢家林,缪娜,柳薇,吉冰洋【摘要】目的评估五种中空纤维膜式氧合器(HFMO)在体外循环(CPB)中不同温度下的跨膜压差(TMPD)。方法40例择期CPB下行心脏直视手术患者依据使用HFMO的不同随机分为五组(每组8例):A组(Affinty),。组(Cobe),丿组(Jostra),卩组(Polystan)和T组(Terumo)。在CPB全流量后(T1)、最低温度吋(T2)、复温后(T3)监测灌注流量、鼻咽温度、红细胞比积、平均动脉压,并在HFM0的入口和出口处监测压力的变化。结果各组术前的临床
2、参数没有显著性差异(P>0.05)。TMPD在不同的时点J组为最小,其他依次分别为A组0.05)。A组、P组和T组在低温过程中的TMPD分别高于T1和T3,但没有显著性差异(P>0.05)。结论J组和A组的TMPD较低可能更有利于减少对血细胞的破坏,更适合应用于CPB吋间较长的心脏手术。【关键词】膜式氧合器;跨膜压差;体外循环;温度Abstract:OBJECTIVEToevaluatefivetypecommercialavailableoxygenatorsofthetrans-membranepressuredrop(TMPD)duringnormotherm
3、icandhypothermiccardiopulmonarybypass(CPB).METHODSFortypatientsscheduledforcardiacsurgeryparticipatedthisstudyandweredividedintofivegroups(n=8,inper-group)accordingtotypeofoxygenatorsusedduringCPB:groupJ(JoatraQuardox),groupA(AffinityNT),groupP(PolystanSafeMaxi),groupT(TerumoCapioxSX)a
4、ndgroupC(COBEAPEX・TM).ParameterswerecollectedduringCPBincludingmeanarterialpressure,pumpflow,temperature,hematocritandTMPDatpre・andpost・oxygenatorduringnormothcrmic(Tl),hypothermic,28°C(T2)andafterrewarming(T3)・RESULTSTherewasnosignificantdifferenceamongfivegroupsinpre・operativeclinica
5、lparameters(P>0.05).TMPDsofgroupJwerethelowestindifferenttime-points,followedbytheothergroupweregroupA6、hangroupC(PcO.Ol)atT1,therewerenostatisticalsignificance(P>0.05)invarioustime-poinfs.AlthoughTMPDsingroupA,PandTduringT2werehigherthanT1andT3,buttherewerenostatisticalsignificance(P>0.05)invarioustime-points.CONCLUSIONTheTMPDofHFMOsingroupJandAproducedsignificantly1owerandduringnormoth7、ermicandhypothermicCPB,thusbloodtraumawiththesetwoHFMOsduringCPBmaybesignificantly1owercomparedtotheotherthree・Keywords:Membraneoxygenato;Pressuredrop;Cardiopulmonarybypass;Hyperthermia随着生物医学工程技术的进步,中空纤维膜式氧合器(hollow-fibermembraneoxygenators,HFMO)的走血方式从纤维内走血变为纤维夕*走血'不仅减小了血流通过HFMO的阻力,同
6、hangroupC(PcO.Ol)atT1,therewerenostatisticalsignificance(P>0.05)invarioustime-poinfs.AlthoughTMPDsingroupA,PandTduringT2werehigherthanT1andT3,buttherewerenostatisticalsignificance(P>0.05)invarioustime-points.CONCLUSIONTheTMPDofHFMOsingroupJandAproducedsignificantly1owerandduringnormoth
7、ermicandhypothermicCPB,thusbloodtraumawiththesetwoHFMOsduringCPBmaybesignificantly1owercomparedtotheotherthree・Keywords:Membraneoxygenato;Pressuredrop;Cardiopulmonarybypass;Hyperthermia随着生物医学工程技术的进步,中空纤维膜式氧合器(hollow-fibermembraneoxygenators,HFMO)的走血方式从纤维内走血变为纤维夕*走血'不仅减小了血流通过HFMO的阻力,同
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