琥珀酸索利那新治疗神经源性逼尿肌过度活动

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1、琥珀酸索利那新治疗神经源性逼尿肌过度活动摘要：目的：评估琥珀酸索利那新治疗脊髓损伤后逼尿肌过度活动的疗效。方法：将36例经尿流动力学检查证实存在逼尿肌过度活动的脊髓损伤患者随机分为2组：对照组18例，给予一般性治疗，如饮水计划、间歇性导尿等；实验组18例，在一般性治疗基础上给予口服琥珀酸索利那新5mg/次，1次/d。两组疗程均为6周。两组患者在治疗前1周及治疗6周后行尿流动力学检查，观察储尿期最大逼尿肌压力、膀胱安全容量变化情况，同时行超声检查，了解治疗前后残余尿量情况，对治疗效果进行评价。结果：两组患者治疗后各观察指标均明显改善（P〈0・001），与对照组相比，实验组患

2、者的储尿期最大逼尿肌压力降低、膀胱安全容量增加更为明显，差异具统计学意义（P〈0.05）,对照组残余尿量减少而实验组残余尿量明显增加（P〈0.01）。结论：琥珀酸索利那新治疗脊髓损伤后逼尿肌过度活动，可降低储尿期最人逼尿肌压力及提高膀胱安全容量，减少尿失禁，有较好的疗效。关键词：琥珀酸索利那新脊髓损伤逼尿肌过度活动Doi：10.3969/j.issn.1671-8801.2013.07.030TheefficacyofsolifenacinsuccinatetherapyinpatientswithNeurogenicdetrusoroveractivityLiuXiao

3、yanXieSumeiLiQingqingelal.Abstract:Objective：ToevaluatetheefficacyandsafetyofsolifenacinsuccinatetherapyinpatientswithNeurogenicdetrusoroveractivity(NDO)afterspinalcordinjury.Methods：Atotalof36patientswithNDOwereenrolledinthetrialandwererandomlydividedintotwogroups,experimentalgroup(n二18)

4、andcontrolgroup(n=18)・Patientsincontrolgroupwereonlyreceivedgeneraltreatment，suchasdrinkingwaterfollowschemeandintermittentcatheterization.Solifenacinsuccinatewastaken5mgonceadayfor6weeksbypatientsinexperimentalgroup.Thecoursesoftreatmentwerelastedforsixweeksinbothgroups.Urinationdiarywas

5、recordedbyallpatientsinbothgroupsoneweekbeforeandaftertreatment.Theefficacyofsolifenacinsuccinatewasassessedbycomparingthechangesofmaximumdetrusorpressure,bladdersecuritycapacityandresidualurinevolumeintwogroups.Result：Aftertreatment,themaximumdetrusorpressureinurinestoragestage,bladderse

6、curitycapacityandresidualurinevolumeweresignificantlyimprovedinbothgroups(P<0.001)•Comparedwithcontrolgroup,themaximumdetrusorpressureinurinestoragestagedecreasedandbladdersecuritycapacityincreasedsignificantly(P<0.05)inpatientsofexperimentalgroup.Theresidualurinevolumeofpatientsweredecre

7、asedincontrolgroupwhileincreasedinexperimentalgroup(P<0.01).Conclusion：Solifenacinsuccinatetherapycanreducethemaximumdetrusorpressureinurinestorage,improvebladdersecuritycapacityandreduceincontinenceinpatientswithNeurogenicdetrusoroveractivityafterspinalcordinjury.K