托特罗定联合清洁间歇导尿和夜间留置导尿治疗儿童神经源性逼尿肌过度活动疗效分析

《托特罗定联合清洁间歇导尿和夜间留置导尿治疗儿童神经源性逼尿肌过度活动疗效分析》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、托特罗定联合清洁间歇导尿和夜间留置导尿治疗儿童神经源性逼尿肌过度活动疗效分析张艳文建国张麵花麵何翔飞冯麵郑州大学第一附属医院小儿尿动力学中心和泌尿外a摘要：目的:评估托特罗定联合清洁间歇导尿（CTC）和夜间留置导尿（CDN）治疗儿童神经源性逼尿肌过度活动（NDO）临床疗效。方法:选取（7.9±2.5）岁NDO患儿44例，按单盲、随机法分为观察组24例（托特罗定联合CIC和CDN治疗）和对照组20例（安慰剂联合C1C和CDN治疗），疗程4周。服药前和治疗4周后分别行尿动力学检查和记录3d排尿日记。结果:共41例患儿完成4周治疗。观察组治疗后首次逼尿肌收

2、缩时容量、膀胱安全容量、膀胱顺应性及每次导尿量较治疗前增大，24h尿失禁次数减少（P<0.05）:对照组治疗后膀胱安全容量、膀胱顺应性较治疗前增大（P〈0.05）;治疗后观察组首次逼尿肌收缩时容量、膀胱安全容量、膀胱顺应性、每次导尿量及24h尿失禁次数的改善情况均好于对照组，差异有统计学意义（P〈0.05）。结论:托特罗定联合CIC和CDN治疗儿童ND0安全有效，可明显减少患儿尿失禁次数，改善患儿生活质量。关键词：儿竜;神经源性逼尿肌过度活动;托特罗定;导尿;尿动力学检查;作者简介：文建国，男，博士，教授，主任医师，研究方向:尿控学，E-mail:j

3、gwen@zzu.edu.cn收稿日期：2017-05-15基金：国家自然科学綦金项目81670689AssessmentoftolterodinecombinedwithcleanintermittentcatheterizationandcatheterizationduringnightinchildrenwithneurogenicdetrusoroveractivityZHANGYanWENJianguoZHANGRuiliHUAGhaoyangHEXiangfeiFENGJinjinPediatricUrodynamicCenterand

4、DepartmentofUrology，theFirstAffiliatedHospital,ZhengzhouUniversity;Abstract：Aim:Toinvestigatetheeffectoftolterodinecombinedwithcleanintermittentcatheterization(CTC)andcatheterizationduringnight(CDN)inchildrenwithneurogenicdetrusoroveractivity(NDO).Methods:Atotalof44childrenwith

5、NDOwereenrolledandrandomlyallocatedintoobservationgroup(n=24)andcontrolgroup(n=20).TheobservationgroupunderwenttolterodinecombinedwithCICandCDNwhilethecontrolgroupacceptedplacebocombinedwithCTCandCDNfor4weeks.Urodynamicdataand3-daybladderdiarieswereobtainedbeforeandafter4weeks.

6、Results:Forty-onepatientssuccessfullycompletedthisstudy.Thefirstdetrusorcontractioncapacity,thesafetybladdercapacity,thedetrusorcomplianceandthepercatheterizationinvolumeoftheobservationgroupincreasedsignificantlyaftertreatment,whilethenumberofincontinenceepisodesper24hdecrease

7、d(P〈0.05).Thesafetybladdercapacityandthebladdercomplianceofcontrolgroupincreasedaftertreatment(P<0.05).Alltheseparametersintheobservationgroupimprovedcomparedwiththoseincontrolgroupaftertreatment(P<0.05).Conclusion:TolterodinecombinedwithCICandCDNissafeandeffectiveintreatmentof

8、childrenwithNDO,whichcansignificantlydecreasethenumber