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时间:2019-11-27
《新生儿高胆红素血症66例临床研究》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、新生儿高胆红素血症66例临床研究[摘要]目的探讨本地区新生儿高胆红素血症的病因,为预防及治疗提供依据。方法将66例高胆红素血症患儿分为换血组(33例)与未换血组(33例)进行病因分析,并对两组患儿的临床特点进行比较。结果两组高胆红素血症的病因均以溶血性因素为首,占62.1%(41例),感染因素占22.7%(15例),原因不明占15.1%(10例)。两组患儿在总胆红素浓度、发现黄染时间、就诊时间和黄疸持续时间等方面进行比较,差异有统计学意义(P2、访和及时就诊,是减少胆红素脑病发病的关键。[关键词]新生儿;高胆红素血症;病因;临床分析[中图分类号]R722.17[文献标识码]A[文章编号]1674-4721(2012)07(c)-0040-02Clinicalanalysisofneonatalhyperbilirubinemiain66casesWANGFengSUNYanDepartmentofPediatrics,the300HospitalofXiaoheDistrietinGuiyangCity,GuizhouProvince,Guiyang550009,China[Abstract]ObjectiveTod3、iscussthepathogenesisofneonatalhyperbilirubinemiainourregion,inordertoprovidebasisforpreventionandtreatment・MethodsThepathogenesisof66casesofhyperbilirubinemiachildrenwhoweredividedintoexchangetransfusiongroup(n二33)andwithoutexchangetransfusiongroup(n=33)wereanalyzed,andtheclinicalfeatureso4、fthetwogroupswerecompared・ResultsThepathogenesisofhyperbilirubinemiainthetwogroupswerethehemolyticfactor,infectionfactorandreasonunknown,whichaccountedfor62.1%(41cases),22.7%(15cases),15.1%(10cases)respectively.Thetotaibilirubinconcentration,stainedyellowfindtime,visitingtimeandjaundicedura5、tiontimewerecomparedbetweenthetwogroups,thedifferenceswerestatisticallysignificant(P<0.001).ConclusionHemolysisandinfectionarethemainreasonsofneonataihyperbilirubinemia・Thehighleveloftotalbilirubinconcentrationandtheinterventiondelayaretheriskfactorsofhyperbilirubinemia・Strengtheningpropaga6、nda,post—dischargeoffollowupandtimelytreatmentarethekeyofreducingtheincideneeofbilirubinencephalopathy.[Keywords]Neonatus;Hyperbi1irubinemia;Pathogenesis;Clinicalanalysis新生儿黄疸是新生儿期最常见疾病,其胆红素代谢紊乱为多种因素所致,严重者可导致胆红素脑病,故及时寻找原因,早期预防,诊断及治疗尤为重要。本研究收集66例高胆红素血症患儿,分析其病因,为临床高胆红素血症的病因学诊断及治疗提供参考。1资料与方法1.7、1一般资料收集2011年8月〜2012年3月本院新生儿科收治的高胆红素血症患儿66例,均为足月儿,日龄在1〜15d,其中,男42例,女24例;体重小于2500g10例,大于2500g56例。将66例患儿分为换血组和未换血组,每组30例。1.2诊断、换血标准新生儿高胆红素血症诊断及换血标准参考《实用新生儿学》新生儿高胆红素血症诊断及换血标准[1],选择在同时期24h内血清胆红素2257umol/L,24〜48h内血清胆红素值2342umol/L,48〜72h内血清胆红素值2428umol/L,72h以上血
2、访和及时就诊,是减少胆红素脑病发病的关键。[关键词]新生儿;高胆红素血症;病因;临床分析[中图分类号]R722.17[文献标识码]A[文章编号]1674-4721(2012)07(c)-0040-02Clinicalanalysisofneonatalhyperbilirubinemiain66casesWANGFengSUNYanDepartmentofPediatrics,the300HospitalofXiaoheDistrietinGuiyangCity,GuizhouProvince,Guiyang550009,China[Abstract]ObjectiveTod
3、iscussthepathogenesisofneonatalhyperbilirubinemiainourregion,inordertoprovidebasisforpreventionandtreatment・MethodsThepathogenesisof66casesofhyperbilirubinemiachildrenwhoweredividedintoexchangetransfusiongroup(n二33)andwithoutexchangetransfusiongroup(n=33)wereanalyzed,andtheclinicalfeatureso
4、fthetwogroupswerecompared・ResultsThepathogenesisofhyperbilirubinemiainthetwogroupswerethehemolyticfactor,infectionfactorandreasonunknown,whichaccountedfor62.1%(41cases),22.7%(15cases),15.1%(10cases)respectively.Thetotaibilirubinconcentration,stainedyellowfindtime,visitingtimeandjaundicedura
5、tiontimewerecomparedbetweenthetwogroups,thedifferenceswerestatisticallysignificant(P<0.001).ConclusionHemolysisandinfectionarethemainreasonsofneonataihyperbilirubinemia・Thehighleveloftotalbilirubinconcentrationandtheinterventiondelayaretheriskfactorsofhyperbilirubinemia・Strengtheningpropaga
6、nda,post—dischargeoffollowupandtimelytreatmentarethekeyofreducingtheincideneeofbilirubinencephalopathy.[Keywords]Neonatus;Hyperbi1irubinemia;Pathogenesis;Clinicalanalysis新生儿黄疸是新生儿期最常见疾病,其胆红素代谢紊乱为多种因素所致,严重者可导致胆红素脑病,故及时寻找原因,早期预防,诊断及治疗尤为重要。本研究收集66例高胆红素血症患儿,分析其病因,为临床高胆红素血症的病因学诊断及治疗提供参考。1资料与方法1.
7、1一般资料收集2011年8月〜2012年3月本院新生儿科收治的高胆红素血症患儿66例,均为足月儿,日龄在1〜15d,其中,男42例,女24例;体重小于2500g10例,大于2500g56例。将66例患儿分为换血组和未换血组,每组30例。1.2诊断、换血标准新生儿高胆红素血症诊断及换血标准参考《实用新生儿学》新生儿高胆红素血症诊断及换血标准[1],选择在同时期24h内血清胆红素2257umol/L,24〜48h内血清胆红素值2342umol/L,48〜72h内血清胆红素值2428umol/L,72h以上血
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