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1、埃索美拉I地治疗反流性食管炎的临床疗效观察作者：朱艳丽，崔颖，刘亮，朱艳丽单位：佳木斯大学附属第一医院消化科，黑龙江佳木斯154003;2.红十字医院核医学科，黑龙江哈尔滨150040【摘要】目的：探讨埃索美拉哇対反流性食管炎(RE)的疗效。方法：用埃索美拉哇40mg,每日一次，治疗52例经内镜证实的反流性食管炎患者。分别于治疗后2、4、6周观察反酸、烧心、反食等症状疗效，并于6周后复查胃镜，观察镜下治愈率，并分别于治疗前后进行食管24hpH临测。结果：埃索美拉哇治疗2周，即可见症状明显改善，症状记分较治疗前明显下降(PV0.01),治疗2、4、6周后，症状治疗显效率分别为5
2、3.84%、78.85%及82.69%,治疗4周及6周后与2周比(P<0.01)o治T6周症状改善总有效率为92.3%o6周后I级食管炎治愈率为93.75%,高于II级74.1%,III级与IV级66.7%(P<0.05)；但各级食管炎改善，即有效率比较差异无显著性。食管24hpH监测，治疗后反流总时间百分率及反流总次数分别由(17.47±5.93)%及(151.2±37.5)次,降至(5.21±0.44)%(P<0.01)及(60.1±14.83)次(P<0.01)。结论：埃索美拉畔是治疗反流性食管炎的有效
3、药物。【关键词】胃食管反流病；反流性食管炎；埃索美拉II坐CurativeeffectoftreatmentofrefluxesophagitiswithesomeprazoleZHUYanli.CUIYing,LIULiangl.TheFirstAffiliatedHospitalofJiamusiUniversity,Jiamusi154003,China;2.RedCrossHospital,Harbin150040,ChinaAbstract:Objective:Toinvestigatetheeffectofesomeprazoleonrefluxesophagit
4、is.Methods：Fifty-twopatientswithendoscopicallyprovenrefluxesophagitisweretreatedwithesomeprasole40mg/d.Refluxsymptomsincludingregurgitation,heartburnandfoodrefulxwereobservedat2,4and6weeksaftertreatment.Endoscopywasperformed6weekslatertoobservethehealingrate,andtheesophageal24hpHwasmonitore
5、d.Results：After2-weektreatmentwithesomeprazole,allthesymptomswereimproved,andsymptomscoresweregreatlydecreased(P<0.01).Theeffectiverateswere53.84%,78.85%and82.69%,respectively2,4and6weeksaftertreatment,andtheeffectiverates4and6weeksaftertreatmentweresignificantlyhigherthantheeffectiverat
6、e2weekaftertreatment(P<0.01).Thetotalsymptomimprovementratewas92.3%at6weeks・After6-weektreatment,theendoscopichealingrateofgradeIesophagitiswas93.75%muchhigherthangradeIIof74.1%andgradeIIIandgradeIVof66.7%(P<0.05).Thepercentageofthetotaltimeofrefluxandthetotalnumberofrefluxdecreasedfr
7、om(17.47±5.93)%and(151.2±37.5)timesto(5.21±0.44)%(P<0.01)and(60.1±14.83)times(P&l(;0・01),respectively.Conclusion：Esomeprazoleiseffectiveinthetreatmentofrefluxesophagitis.Keywords:gastroesophagealrefluxdisease;refluxesophagi
