四联疗法治疗消化性溃疡79例分析

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1、四联疗法治疗消化性溃疡79例分析【关键词】四联疗【摘要】H的探讨四联疗法对消化性溃疡的治疗作用及根除幽门螺杆菌的效果。方法将102例胃镜证实为消化性溃疡者随机分为3组，Am48例给于养胃舒1.2g+雷尼替丁150mg+阿膜两林500m計甲硝I坐400mg,bid;B纟

2、[31例给沖铤剂220mg+雷尼替丁150mg+阿莫西林500mg+甲硝®400mg,bid;对照组（C组，23例）给予雷尼替丁150mg+阿莫西林500mg+甲硝啤400mg,bid;以上药物除抗菌药物只服用2周外，其余药物服至6周末疗程结束，

3、第7周复查胃镜和（或）13C呼气试验。结果溃疡总愈合率A组、B组、C组分别为90.9%、100%、86.4%,S2获得率分别为68.2%,73.1%和45.5%,Hp根除率分别为73.3%,76.1%和52.6%,症状缓解率大致相似，3组无明显不良反应发牛。结论雷尼替丁三联疗法加用锯剂和养胃舒均可使S2获得率增加，同时Hp根除率上升，临床观察无明显不良反应。关键词消化性溃疡幽门螺杆菌药物治疗vPstyle二“TEXT-INDENT:24px“align=center>Analysisofquadruplereg

4、imensforthetreatmentof79patientswithpepticulcerdiseaseZhaoGang,QianXuelanTheCentralHospitalofJianghanOilField,HubeiQiangjiangCity433124.[Abstr

5、act]ObjectiveTostudytheefficaciesofquadrupleregimensforthetreatmentofpepticulcerdiseaseanderadicationofHelicobacterpylori（Hp）・Methods102patientswithHpassociatedpepticulcerwererandomlydividedintothreegroups»groupA（n=98）receivedsanjiuweitai-basedquadrupleregim

6、en（Yangweishul.2g,bid+ranitidinel50mg,bid+amoxicillin500mg,bid+metronidazole400mg,bid）;groupB（n=31）receivedcolloidalbis一muthsubcitrate（Livzon）llOmg,bid+ranitidinel50mg,bid+amoxiciHin500mg,bid+metronidazole400mg,bid;groupC（n=23）receivedranitidine150mg,bid+amo

7、xicillin500ing,bid+metronidazole400mg,bid.Antibioticsweregrivenfortwoweeks,theotherdrugsweregivenforsixweeks,theefficaciesweredeterminedbygastroendoscopyor13C—UBT.ResultsTheulcerhealingratewere90.9%,100%,86.4%introupA,B,Crespectively;thestageS2achievementrat

8、ewere68.2%»73.1%and45.5%;theeradicationrateofHpwere76.1%,73.3%and52.6%,thesymptomswereremissivesiinilarlyinthieegroups,therewerenosideeffectsinthreegroups.ConclusionRaniti'dine—basedtripleregimenplusLivzonorYangweishucanraisethestageS2achievementrateandHpera

9、dicationrate.Threewasnosideeffect.Keywordspepticulcerhelicobacterpyloridragstherapy胃酸、幽门螺杆菌（Hp）与消化性溃疡（PU）的关系己被公认，胃酸过多的消化性溃疡要降酸，Hp阳性者要予抗菌治疗，日前国内外多主张四联疗法，三联疗法逐渐被四联疗法所取代。1999年5刀〜2003年12刀本院采川四联疗法治疗消