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1、利培酮合并氯内咪嗪治疗强迫症临床分析【摘要】「【的：比较利培酮合并氯丙咪嗪对强迫症的临床疗效及不良反应。方法：按前瞻性、随机单盲法，将67例强迫症患者随机分为利培酮合并氯丙咪嗪组和氯丙咪嗪组，疗程10周。在疗前，疗后2、4、6、8、10周用Yale-Brown强迫量表(Y-BOCS),汉密尔顿焦虑量表(HAMA),汉密尔顿抑郁量表(HAMD),副反应量表(TESS)和临床疗效评定标准，评定疗效及不良反应。结果：利培酮介并氯丙咪嗪组起效快，第2周末吋各分值与治疗前比较差异有显著性(PvO.05)。两组从第4周末始各分值与治疗前比较差异
2、均有极显著性(PvO.Ol)。第4、6、8、10周两组间各分值比较差异均有显著性(PvO.05)。利培酮合并氯丙咪嗪组总体疗效优于氯丙咪嗪组，两组有效率差异有显著性(PvO.05),两组不此反应发牛率均较低，差界无显著性(PvO.05)。结论：利培酮合并氯丙咪嗪治疗强迫症较氯丙咪嗪好，起效快，依从性好，不良反应轻，值得推广。【关键词】神经症；强迫症；利培酗;氯丙咪嗪TheclinicalanalysisofRisperidoneandClomipramineinthetreatmentofobsessive-compulsivedi
3、sordersWANGYu-wei,CAOLi-hua,YANGLi-qin,etal(TheSecondPeopleHospitalofDeZhou,Shandong253022,China)【Abstract］Objective:TocomparetheefficacyandsideeffectsofRisperidoneandClomipramineinthetreatmentofobsessive-compulsivedisorders(OCD).Methods:Sixty-sevenpatientswererandomiz
4、edtoRisperidoneandClomipraminegroupandClomipraminegroupaccordingtoforesightandsingle-blindfor10weeks・TheefficacywasmeasuredwithY-BOCS,HAMAandHAMDandthesideeffectsweredeterminedbyTESSbeforeandafterthesecond,fourth,sixth,eighthandthetenthweek.Results:RisperidoneandClomip
5、raminegrouptookeffectquickly.Attheendofthesecondweek,therewasmarkeddifferencethanbefore(P<0.05).Butthetwogroupsbothtookeffectobviouslyattheendofthefourthweek(P<0.01).Andtherewasmarkeddifferenceinthefourth,sixth,eighthandtenthweekbetweenthetwogroups(P<().()5).Risperidon
6、eandClomipraminegroupismoreefficiethantheClomipraminegroup.Therewasthemoreobviousdifferencebetweeneffectiverateoftwogroups(Pv0・05)・Thesideeffectsoftwogroupsarebothlow.Therewasnomarkeddifference(Pv0・05).Conclusions:ItisbettertousebothRisperidoneandClomipraminethanonlyto
7、useClomipramine.ThecombinationofRisperidoneandClomipramineisaneffectivemethodwithfewsideeffectsandtakesintoeffectrapidlyinthetreatmentofOCDandhasbetterresponseinobsessivethoughts・【Keywords］Neurosis;Obsessive-compulsivedisorder;Risperidone;Clomipramine强迫症(OCD)作为常见而难治的精神
8、障碍［1］,目前对其较有效的治疗有：优先作用于五疑色胺(5-HT)的回收抑制剂(PSRIs)和多巴胺D2受体阻断剂(如利培酮)［2-6］。国外研究发现利培酮合并PSRIs治疗OCD较单用PSRIs效果更好［1,3,7-9］。国内对此报
