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1、嘉兴市全球基金耐多药肺结核防治策略分析[摘要]目的分析嘉兴市全球基金耐多药肺结核防治策略实施效果,为今后耐多药肺结核发现、控制提供依据。方法对嘉兴市2013年1月1日〜2015年6月30日可疑耐多药肺结核筛查、耐多药肺结核发现、治疗等监测数据进行回顾性分析。结果嘉兴市全球基金耐多药肺结核项目期内筛查可疑耐多药肺结核患者1636例,筛查率77.98%,培养阳性率71.03%,培养报告时间4〜28d,平均(16.00±4.52)d;筛查出耐多药肺结核患者45例,检出率2.75%;初始耐多药患者21例,初始耐多药率1
2、.63%,复治耐多药患者25例,复治耐多药率6.96%,差异有统计学意义(x2=25.88,P<0.05);2013-2015年检出率呈逐渐下降趋势;其中28例患者(62.22%)进行了标准化方案治疗、患者6个月末痰菌转阴率为80.77%O结论嘉兴市全球基金耐多药肺结核防治模式取得阶段性成效,但复发患者纳入治疗率低,初始耐药与获得性耐药并存,规范复治管理、扩大初治筛查、改进诊断方法、阻断传播等问题需要今后解决。[关键词]结核;肺;耐多药;防治;策略;肺结核[中图分类号]R52[文献标识码]B[文章编号]1673
3、-9701(2016)07-0131-05[Abstract]ObjectiveToanalyzetheimplementationeffectofmultidrugresistanttuberculosisofglobalfundinJiaxingandprovideevidenceforthefurtherexplorationandcontrolofmultidrugresistanttuberculosis.MethodsThemonitoringdataofsuspiciousmultidrugres
4、istanttuberculosisscreening,multidrugresistanttuberculosisexplorationandtreatmentfromJanuary1st,2013toJune30th,2015wasretrospectivelyanalyzed.Results1636casesofsuspiciousmultidrugresistanttuberculosiswerescreenedduringtheGlobalFundMultidrugResistantTuberculo
5、sisProjectandthescreeningratewas77.98%,cultivationpositiveratewas71.03%,cultivationreporttimewas4to28dayswithanaverageof16.00±4.52days;45casesofmultidrugresistanttuberculosiswerescreenedoutwiththedetectionrateof2.75%;21casesofprimarymultidrugresistanttubercu
6、losiswithaprimarymultidrugresistantrateof1.63%;25casesofretreatmultidrugresistanttuberculosiswitharetreatmultidrugresistantrateof6.96%・Thedifferenceshadstatisticalsignificanee(x2=25.88,P〈0・05);thedetectionratepresentedagradualdecreasingtrendfrom2013to2015・28
7、patients(62.22%)weregiventhestandardtreatmentschemeandaftersixmonths,thesputumnegativeconversionratewas80.77%.ConelusionThepreventivemodeofmultidrugresistanttuberculosisofGlobalFundinJiaxinghasgainperiodicalsuccess,howevertherearealsoproblemsneedingtobesolve
8、d,forinstance,lowincludingtreatmentrateofrelapsepatients,co-cxistonceofprimarymultidrugresistanceandacquiredmultidrugresistanee,retreatmentadministration,initialtreatmentscreening,diagnosticmeth