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1、ExperimentalstudyofWanBiqingpilltreatmentratsadjuvantarthritisLiXingxing(OrthopaedicsandTraumaofTraditionalChineseMedicine)DirectedbyZhangYonghongAbstractObjective:ThistopicresearchobjectisWanBiqingpill,itwasguidedbyChinesemedicinedialecticalanddrugthecompatibilityofthetheory.It'smaintreatmentiscoo
2、landremoveblooddredgecollaterals.Aftertousedinratsadjuvantarthritisanimalmodels,Wcobservedjointswelling,determinatedtheStrychniofratadjuvantarthritis(AA)animalmodelofbloodIL-1(IL-1)andtumornecrosisfactor(TNF-a),andfurtherdiscussitsrheumatoidarthritis(RA)regulationoftheimmunemechanism,Toproviderefer
3、enceforclinicaltreatmentofthisdiseaseMethods:Theexperimentused48maleSDratsforthestudywererandomlydividedintofivegroups,namely,thenormalgroup(I),modelgroup(II)，totalrootofherbaceouspeonyglucosidecapsulegroup(Ill),WanBiqinglowdosegroup(IV),WanBiqingmiddlegroup(V),WanBiqinghighdosegroup(VI),8ineachgro
4、up.Injecttherightrear-toeoftheII、IIIIV、V、VIgroupswithCFAtocauseinflammation.After18hours，whenthismodelweresuccessfullymade,infusesteamedwater2mled-lfrommouthingroupIandII,groupIIIwasgiventotalrootofherbaceouspeonyglucosidecapsule0.15g・kg-l・d・lfrommouth,groupIV>V>VIwasgivenWanBiqingpillfrommouthby0.
5、50gekg-led-l、1.0Og・kg・led-land2.00g•kg-1ed・1.After14daysadjustthedosage,duringthedeterminationtomedicineregularlyratweightandvolumeoflowerlimbstoes.28dayslaterthecytokineslevelofIL-1andTNF-afromtherats'serumwasdetected・Results:①Overtime,WanBiqingpillsandrootofherbaceouspeonytreatmentgrouptorattoess
6、wellingimprovemoreandmoreapparent,modelgroupthedegreealwaysthehighest.②ThelevelofTNF-aandIL-1inmodelgroupoflevelobviouslyisonthehighside,andthenormalgroup,WanBiqinghighdosegroupandtotaldosegroupofrootofherbaceouspeonyglucosidecapsulegroupcomparedwithallhavesignificantdifferences(P<0.05).WanBiqingpi
7、llhighdosegroupandAbstracttotalrootofherbaceouspeonyglucosidecapsulegroupcomparedwithnoobviousdifference(P>0.05).③ThelevelofTNF-QandIL-1intheWanBiqinglowdosegroupandWanBiqinghighdosegroupmodelgroupweresigni
