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1、鮭鱼降钙素联合钙尔奇D治疗糖尿病伴骨质疏松疗效观察【摘要】目的探讨鮭鱼降钙素联合钙尔奇D治疗糖尿病伴骨质疏松症患者的疗效及安全性。方法16例糖尿病伴骨质疏松症患者用鮭鱼降钙素50IU1次/d,肌肉注射,同时服用钙尔奇D.600mg/d,连续治疗4个周。在治疗前、治疗后分别测量骨密度(BMD).骨代谢指标骨钙素(BGP),血钙、血磷、肝肾功能等,观察骨质疏松症腰背疼痛症状的治疗效果。结果治疗4个周后骨密度较治疗前明显升高,骨钙素显著高于治疗前,甲状旁腺激素和碱性磷酸酶二者显著减低,腰背疼痛等骨病症状减轻甚至消失。结
2、论鮭鱼降钙素加钙尔奇D能够抑制骨吸收,促进骨形成,降低骨转换,并能迅速改善腰背疼痛症状,对糖尿病伴骨质疏松症治疗效果显著。【关键词】糖尿病;骨质疏松;鮭鱼降钙素;钙尔奇DTheEfficacyofSalmonCalcitonincombinedwithCaltrateDinTreatmentofDiabetesMellituscomplicatedwithOsteoporosisDAILing.EighthPeople,sHospitalofZiboCity,ShandongProvince,Zibo255000
3、,China[Abstract】ObjectiveTostudytheefficacyandsafetyofsalmoncalcitonincombinedwithcaltrateDintreatmentofdiabetesmellituscomplicatedwithosteoporosis.Methods16patientswithdiabetesmellituscomplicatedwithosteoporosisweregivensalmoncalcitonin,50IU,im,qd,andcaltrat
4、eD600mg/dfor4weeks.The作者单位:255000山东省淄博市第八人民医院bonemineraldensity(BMD),bonemetabolicmarkersosteocalcin(BGP),serumcalcium,phosphorus,liverandkidneyfunctionweremeasuredbeforeandaftertreatmenttoobservethetreatmenteffectofosteoporosiswithpainonlowback.ResultsAfter4
5、weeksoftrea.tmenttheBMDandBGPweresignificantlyhigher,parathyroidhormoneandalkalinephosphataseweresignificantlylower,thesymptomsofbonediseaselikethelowbackpainreducedordisappeared.ConclusionSalmoncalcitonincombinedwithcaltrateDcaninhibitboneresorptionandpromot
6、eboneformation,reducebonechange,andrapidlyimprovethesymptomsoflowbackpain,andhassignificanteffectintreatmentofdiabetesmellituscomplicatedwithosteoporosis・[Keywords】Diabetesmellitus;Osteoporosis;Salmoncalcitonin;CaltrateD糖尿病伴骨质疏松是临床上很常见的现象,是由于糖尿病患者胰岛素绝对或相对缺乏导致
7、机体糖、蛋白质、脂肪代谢紊乱,钙、磷、镁等微量元素代谢障碍引起骨组织量减少,甚至出现病理性骨折的代谢性骨病。其发病率各文献报道不一,国内外报道为9.8%〜66%,可能与测定方法,选择对象及诊断标准不同有关。国外报道近半数糖尿病患者发生骨质疏松,以NIDDM居多[1],国内报差距更大14.6%~66%⑵,主要与空腹血糖及血糖控制程度有关,而与年龄无关,经常处于高血糖状态的病情控制不良者易发生骨质疏松,事实上属于继发症,该疾病是近几年才开始被医学界认识。Levin[3]报道糖尿病患者中有50%合并骨质疏松,而骨质疏松
8、一旦发生,不可逆转,所以重在预防。我院自2008至今用鮭鱼降钙素联合钙尔奇D治疗糖尿病伴骨质疏松症患者16例,取得了较好的效果,总结报告如下。1资料与方法1.1一般资料所选糖尿病伴骨质疏松症患者16例,其中女10例,男6例,全部来自门诊就诊和病房住院患者,年龄51~78岁,病程一般为广5年。经X线骨密度仪检测骨矿密度(BMD),并且均伴有不同程度骨痛、抽搐、腰背酸痛等临床