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1、绝经后妇女血脂代谢的变化及激素替代治疗的影响【关键词】血脂［摘要］目的：探讨绝经后妇女血脂代谢的变化及激素替代治疗的影响，了解性激素对冠心病发病的影响。方法：选取453例绝经前、围绝经期、绝经后妇女，分别测定其血清中的雌二醇(E2)、孕酮(P)、促卵泡生成素(FSH)、黄体生成素(LH)4项性激素和总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)4项血脂指标，并对58例绝经后妇女进行激素替代治疗(HRT)6个月后再重新测定其血清中的脂类。结果：绝经后妇女E2水平较绝经前及围绝经期妇女有明显下降(P〈001),后两者无明显差异(
2、P>005),绝经后与围绝经期妇女的FSH及LH均较绝经前妇女明显升高(P〈001),绝经后较围绝经期升高更明显，两者比较有显著差异(P<001):绝经后与绝经前妇女血脂水平相比TC、TG、LDLC水平明显升高而HDLC水平明显下降(P〈001),绝经后妇女E2与TC、LDLC水平呈负相关，与HDLC水平呈正相关。58例HRT6个月后,LDLC明显下降,IIDLC明显上升(P〈005)。结论：绝经后妇女血脂异常与体内性激素水平下降有关,HRT对心血管有保护作用。[关键词]血脂；性激素；绝经ChangesofLipoproteinMetabolisminPostmenopaus
3、alWomenandtheEffectsofHormoneReplacementTherapyonItWANGIlongzhenl,CHENJi2,LICaihongl(1.DepartmentofClinicalLaboratory,2.DepartmentofWomenHealthCare,theAffiliatedFourthHospitalofJiangsuUniversity,ZhenjiangJiangsu212001,China)[Abstract]Objective:Toobservethechangesoflipoproteinmetabolisminpos
4、tmenopausalwomenandtheeffectsofHRTonit.Methods:Therewere453womenincluding140premenopausalwomen,135perimenopausalwomenand178postmenopausalwomen,whoseserumhormone(E2,P,FSII,LII)andlipoprotein(TC,TG,IIDLC,LDLC)weremeasured・Amongthem,58postmenopausalwomenwerebeinghormonereplacementtherapy.Sixmo
5、nthslater,serumlipoproteinwereremeasured・Results：①TheserumlevelsofE2inpostmenopausalwomendecreasedsignificantlyascomparedwiththoseinpremenopausalandperimenopausalwomen(P<001).②TheserumlevelsofFSHandLHinpostmenopausalandperimenopausalwomenincreasedsignificantlyascomparedwiththoseinpremenopau
6、salwomen(P<001).Andthoseinpostmenopausalwomenincreasedmoresignificantlythanthoseinperimenopausalwomen(P<001).③TheserumlevelsofTC、TG、LDLCinpostmenopausalwomenincreasedsignificantlyandwhoseserumlevelsofHDLCdecreasedsignificantlyascomparedwiththoseinpremenopausalwomen(P<001).④Therewasanegative
7、significantcorrelationoftheserumlevelsofE2withtheserumlevelsofTC,LDLC,LDLC/HDLCandTC/HDLC.inpostmenopausalwomen.(P〈005)⑤AfterHRTsixmonth,theserumlevelsofLDLCdecreasedsignificarrtlyandtheserumlevelsofHDLCincreasedsignificantly(P<005)・Conclusion：Theabnorma
