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1、男性型脱发患者头皮雄激素受体表达探究［摘要］目的：了解男性型脱发患者头皮雄激素受体(androgenreceptor,AR)表达情况。方法：对来自10例男性AGA患者和3例正常人的头皮，采用免疫组化的方法检测男性型脱发患者头皮不同区域AR的表达。结果：患者不同部位总的AR表达比较，均有明显差异(P0.05)，但均明显强于正常对照组(P0.05'结论：男性型脱发患者不同区域头皮AR的表达是有区别的；毛囊隆突部和漏斗部，交界区及脱发区AR表达明显增强，可能是男性型脱发的重要原因之—。［关键词］男性型脱发；雄激素受体［中图分类号］
2、R758.71［文献标识码］A［文章编■^］1008-6455(2012)05-0778-04AndrogenreceptorexpressioninmalepatternbaldnesspatientsHUANGTao1,2,WANMiao-jian1,DONGJia-hui1,3,FENGZhi-ying4,XIEXiao-yuan1,LIYing1,5丄AlWei1,JIBin6(I.DepartmentofDermatology,The3rdAffiliatedHospitalofSunYat-SanUniversi
3、ty,Guangzhou510630,Guangdong,China;2.DepartmentofDermatology,TheFirstAffiliatedHospitalofGuangxiUniversityofChineseMedicine;3.HuizhouMunicipalDermatosisHospital;4.DepartmentofPathology,The3rdAffiliatedHospitalofSunYat-SanUniversity;5.DepartmentofDermatology,Guangzh
4、ouTheEighthMunicipalPeople'sHospital6.GuangdongYuexiuPlasticSurgeryHospital)Abstract:ObjectiveToinvestigateAR(androgenreceptor)expressioninmalepatternbaldness・MethodsObtainfolliclesfromdifferentscalpareas(occipitalareaofnon・hairloss,hairlosstransitionandhairlosszon
5、earea)of10maleAGA(androgeneticalopecia)patientsand3normalscalp・UseimmunohistochemistrymethodtostudyARexpressionsinhairfolliclesindifferentregions.ResultsInthehairfolliclebulgeandinfundibulum,ARexpressionsinhairlossareaandthetransitionalareaareobviouslystrongerthant
6、hoseintheoccipitalandthenormalcontrolgroup(P0.05)inoccipitalarea,hairlossareaandthetransitionalarea,buttherearesignificantdifferencescomparedtonormalcontrolgroup(P0.05)・ConclusionTheARexpressionsaredifferentbetweendifferentregions.Inthehairfolliclebulgeandinfundibu
7、lum,ARexpressionsinhairlossareaandthetransitionalareaareobviouslystrongerthanthoseintheoccipital.Thismaybeoneofthekeyfactorsleadingtomalepatternhairloss・Keywords:malepatternbaldness,androgenreceptor雄激素和遗传因素在雄激素源性脱发（AGA）发病过程起着重要的作用口］。雄激素的生物活性是由细胞内的雄激素受体所介导，雄激素受体（and
8、rogenreceptorAR）存在于表皮、毛囊角质细胞、皮脂腺和汗腺等细胞和组织中。既往的研究发现脱发区与非脱发区真皮乳头细胞上AR表达是有区别的［2］，但并没有阐明AGA患者其它部位AR受体表达以及与正常人对照是否有差异。笔者推测在AGA患者中，脱发区不同部位的AR表达是有区别的，这在
