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1、来曲醴二种剂量促排卵的临床观察【摘要】目的比较芳香化酶抑制剂-来曲哇(letrozole,LE)2种不同剂量的促排卵的临床疗效。方法将68例II型生殖内分泌异常的不育妇女随机分为2组，其中2.5mg组33例，5.0mg组35例，2.5mg组口服LE2.5mg,5.0mg组口服LE5.0mg,均每天1次，连续服用5do2组均于月经周期的10d开始作阴道B超监测，隔天1次最大卵泡平均直径(MFDX10mm,肌注人绝经促性腺激素(HMG)75IU,每天1次，连续3d后如无优势卵泡出现，则肌注HMG150IU,每天1次，至优势卵泡MFD^18mm时，肌注人
2、绒毛膜促腺激素(HCG)10000IUo结果HCG日$15mm卵泡个数，5.0mg组多于2.5mg组，卵泡成熟所需天数5.0mg组少于2.5mg组，2组比较，差异均有统计学意义(P<0.01);单用LE优势卵泡出现率、三线征阳性率、HCG日子宫内膜平均厚度、HCG日最大卵泡MFD,2组比较，差异均无统计学意义;2.5mg组临床妊娠率为15.2%(5/33),5.0mg组为17.1%(6/35);2组均未出现卵巢过度刺激综合征及卵泡未破黄素综合征。结论來曲I坐用于II型生殖内分泌异常的促排卵治疗吋，可以先使用2.5mg方案，反应不良时可改用5.0mg
3、o【关键词】不育不孕；来曲醴；促排卵ClinicalstudyontheeffectsoftwodosesofLetrozoleonovulationinduetionLIUjuan,LIANGRuining,XUling,eta1.GanzhouMaternityandInfantHea1thHospital,Jiangxi341000,China[Abstract]ObjectiveTocomparetheclinicaleffectoftwodosesof-letrozole(LE)onovulationinduetion.MethodsSi
4、xty-eightinfertiledwomenwithtypeIIabnormalreproductiveendocrinewererandomlydividedintotwogroups,33womenwereinthe2.5mggroupand35womeninthe5.0mggroup.Thewomenintwogroupstook2.5mgor5.0mgletrozoleonceadayfor5days・Beginninginthe10thdayafterthemenstrualperiodbothgroupsreceivedthevag
5、inalultrasonicexaminationoncepertwodays.IfthebiggestfollicleMFD<10mm,thewomenreceivedhumanmenopausalgonadotropin75IUonceadayfor3days・Iftherestillwasn’tanydominantfollicle,thewomen,recievedHMG1501uonceadayuntillthedominantfollicleMFD≥18mm.,Thenthewomenwasgivenhumanchor
6、ionicgonadotropin(HCG)10000IUviaintramuscularinjection.Results5.0mggrouphadmorefollicleswith≥15mmthan2.5mggroupintheHCGdays,whilethedaysforfolliclematurityin5・0mggroupwassignificantlylessthanin2.5mggroup(P〈0.01);NosignificantdifferencewasfoundbetweentwogroupsinLEdominantfol
7、licleapprearancerate,thepositiverateofendmetrialdevelopment,averagethicknessofendometriumintheIICGdays・Thepregnancyratewas15.2%for2.5mggroup,17.1%for5.0mggroup.Bothgroupsdidn’thaveovaryoverstimulationsyndromeandluteinizingunrupturedfolliclesyndrome・ConclusionForthetreatm
8、entoftypeIIabnormalreproductiveendocrinewithletrozole,Itmaybe
