来曲唑用于不孕症促排卵作用的临床研究

《来曲唑用于不孕症促排卵作用的临床研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、来曲卩坐用于不孕症促排卵作用的临床研究作者单位：525000广东省茂名市人民医院通讯作者：陈文慧【摘要】目的将不孕症多囊卵巢综合征(PC0S)患者58例分别用來曲醴(LE)与克罗米酚(CC)治疗促排卵，比较两纽药物对卵泡发育及子宫内膜的影响。方法选择PCOS58例随机分成两纟R服药促排卵，服用来曲醴(LE)30例为治疗组，服用克罗米酚(CC)28例为对照组，观察两组卵泡发育及了宫内膜的影响及妊娠率。结果来曲哩组出现优势卵泡21例(70.0%),克罗米酚组8例(28.6%),两组比较差异有统计学意义(PV0.01)：HCGSLE组^16mm卵泡数明显少于CC组，了宫内膜厚度较厚；L

2、E组奸娠率高于CC组；CC组出现1例卵巢过度刺激综合征，2例出现卵巢早衰。结论来曲哇促排卵效果好，单卵泡发生率高，降低卵巢过度刺激综合征，妊娠率高。克罗米芬对卵巢过度刺激易引起卵巢早衰。【关键词】来曲峰；克罗米酚；不孕症；卵巢早衰ClinicalresearchontheuseofLetrozdeforpromotingovulationinfemaleinfertilingCHENWen-hui,LIN-Jian.ThePeople'sHospitalofMaoming,MaomingCity525000,China[Abstract]ObjectiveAtotalof58ca

3、sespatientswithpolycysticovariansyndrome(PCOS)arerespectivelytreatedbyletrozole(LE)andclomiphenecitrate(CC)forpromotingovulation,thencomparingtheeffectsoftwokindsofdrugsonfolliclegrowthandendometrium

4、s,treatedbyLE;controlgroupof28cases,treatedbyCC・Thefolliclegrowth,effectsonendometriumandpregnancyrateintwogroupswereobserved.Results21caseshaddominantfollicleinthegrouptreatedbyLE(70.0%)and8caseshaddominantfol1icleinthegrouptreatedbyCC(28%),inwhichthedifferenceshadstatisticalsignificanee(P<0

5、・01).DuringtheHCGperiod,thefolliclesthatgreaterthanorequalto16niminLEgroupwereobviouslylessthanthoseinCCgroup,thethickncssofcndometriumwasbiggerandthepregnancyratewashigherrespectivelythanthatinCCgroup・Only1casehadovarianhyperstimulationsyndromeand2casehadprematureovarianfailureinCCgroup.Conc

6、lusionUsingtheLEtopromoteovulationiseffectivewithhighincidenceofsinglefollicleandhighrateofpregnancyandalsocoulddroptheincidenceofovarianhyperstimulationsyndrome・Thehyperstimulationofclomiphenocitrateonovarywouldeasilycausetheprematureovarianfailure.[Keywords]Letrozole;Clomiphenecutrate;Femal

7、einferti1ity;Prematureovarianfailure多囊卵巢综合征(polycysticovariansyndrome,PCOS)是育龄期妇女最常见的内分泌紊乱疾病，占无排卵性不孕患者的l/3^[1],无排卵或排卵障碍是引起不孕的主要原因Z—。现在一般常用的促排卵药物冇克罗米芬(clomiphcnecitratc,CC),但其直接或间接彩响内源性激素平衡，干扰子宫内膜的正常发育和内膜与胚泡发育的同步性，影响内源性笛体激素対子宫内膜的牛理调节