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1、胆红素水平与冠状动脉病变关系的临床研究作者：曾凤兰，张云，赵春丽，邙口禹,韦永强单位：530001南宁，广西民族医院心内科【摘要】目的探讨胆红素水平与冠状动脉病变之间的关系。方法对196患者进行冠状动脉造影。根据冠状动脉病变情况分为4组；冠状动脉止常组(n=30).轻度狭窄组(n=36)、中度狭窄组(n=52)和重度狭窄组5=78)。检测各组患者总胆红素、直接胆红素、间接胆红素、总胆固醇(TC)、三酰甘汕(TG)、高密度酯蛋白胆固醇(HDLC)、低密度酯蛋口胆固醇(LDLC)水平，并进行各组间比较。结果冠状动脉正常
2、组和轻度狭窄组，血浆总胆红素、直接胆红素、间接胆红素均止常，而中度狭窄组和觅度狭窄组均明显降低，与止常组和轻度狭窄组比较差异均有统计学意义(P<0.01)o中度狭窄组、重度狭窄组血TC、LDLC均升高，HDLC均降低与正常组和轻度狭窄组比较差异有统计学意义(P<0.05)o结仑血中胆红索水平与冠状动脉病变呈负相关。【关键词】胆红素；冠状动脉疾病TherelationshipbetweentotalbilirubinlevelsandseverityofcoronaryailerylesionsZENGFenglan
3、,ZHANGYun,ZHAOChunli,etal.NationalHospitalofGuangxiProvince,Guangxi,Nanning530001,China［Abstract］ObjectiveToinvestigatetherelationshipbetweenplasmatotalbilirubinlevelsandseverityofcoronaryarterylesions.Methods196patientswhounderwentcoronaryangiographywereenrol
4、ledinthestudy.Thepatientsweredividedintofourgroupsaccordingtothepathologicalstateofcoronaryartery:normalgroup(n=30),mildstenosisgroup(n=36),mediumstenosisgroup(n=52)andseverestenosisgroup(n=78).Theplasmatotalbilirubin,totalcholesterol(TC),triglycerides(TG)Jowe
5、rdensitylipoproteincholesterol(LDLC),highdensitylipoproteincholesterol(HDLC)weredeterminedinallpatients.Thecoronaryarterylesionswereobservedbyangiographicimagingmanipulationsystem.TheseverityofcoronaryarterydiseasewasdetectedaccordingtoamodifiedGensiniscore.Re
6、sultsThetotalbilirubin,indirectbiliiubinanddirectbilirubinwereobviouslylowerinmediumstenosisgroupandseverestenosisgroupthanthoseincoronaryarterymildstenosisgroupandnormalgroup(P<0.01).ThelevelsofTC,LDLCwereobviouslyincreasedinmediumstenosisgroupandseverestenos
7、isgroupwhileHDLCsignificantlydecreased,therewasasignificantdifferencebetweennormalgroup,mildstenosisgroupandmediumgroup,severestenosisgioup(P<0.05).ConclusionTheplsmabilimbinlevelsarenegativelycorrelatedwiththeseverityofcoronaryarterylesions.【Keywords］Bilirubi
8、n;Coronaryarterydiseases高血压、血脂异常、吸烟、糖尿病是逖心病的高度危险因索，但近年來，血清胆红索水平与冠心病关系成为心血管领域研究热点之一，认为冠心病患者存在低胆红索血症［1］。碗发现［2,3］：血清胆红素水平与冠状动脉狭窄程度呈负相关，冠状动脉狭窄程度越重，血淸胆红素水平越低。本文通过196例冠状动脉造影患者的血淸胆红素水平观察，
