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1、芪苈强心治疗心力衰竭的免疫调节作用华中科技大学协和医院心血管病研究所生物靶向治疗教育部重点实验室廖玉华ICUHInstituteofCardiologyUnionHospital芪苈强心的药理药效Clinicaltrial:ImproveheartfunctionofanimalswithheartfailureSafeandeffectiveforheartfailurecausedbycoronaryheartdiseaseBasictrial:基本功能主要成分：黄芪、人参、附子、丹参、葶苈子、泽泻、玉竹、桂枝、红花、香加皮、陈皮急性心肌梗死后
2、心肌炎症与免疫应答LiaoYH,etal.MolecularCardiologyofChina,2002;2(3):7-9MIareaofpost-MInon-MIareaofpost-MI为什么选择芪苈强心胶囊研究心衰治疗和免疫调节?XiaoH,…LiaoYH,etal.CellImmunol.2009;260(1):51-5.研究方法crudedrugofQiliqiangxinof4g/kg/ddissolvedin1.5mlnormalsaline1.5mlnormalsalineXiaoH,…LiaoYH,etal.CellImmunol
3、.2009;260(1):51-5.Group1week4weeksMI1MI-Q1S1MI4MI-Q4S4LVEDd(mm)5.4±0.3**4.5±0.33.5±0.26.2±0.8*4.7±0.5**3.2±0.5EF(%)56±18*76±7**85±842±3*79±8*92±3FS(%)26±10*39±7**50±818±2*42±9**58±4*meansP＜0.05,**meansP＜0.01芪苈强心改善AMI大鼠心功能（UCG评价）XiaoH,…LiaoYH,etal.CellImmunol.2009;260(1):51-5.E
4、SEDMI-Q4MI4MI-Q1MI1S芪苈强心不减少淋巴细胞在AMI大鼠心肌浸润###Lymphocytescount##meansP＜0.05,comparewithSgroupMIMI-QS1w4wThelymphocytescountresultshowed: nosignificantdifferencebetweenMI&MI-Qgroups(P＞0.05)XiaoH,…LiaoYH,etal.CellImmunol.2009;260(1):51-5.芪苈强心改善AMI心肌的细胞因子基因表达（RealquantitativePCR评价）
5、*meansP＜0.05,**meansP＜0.01Group1week4weeksMI1MI-Q1S1MI4MI-Q4S4TNF-α26.50±7.06**1.70±0.703*0.61±0.18137.0±33.99**14.46±2.23*3)0.29±0.147IL-107.27±3.099*85.94±30.08*0.81±0.155.01±1.150**1)180.8±27.39*3)0.33±0.102TNF-/IL-103.91±0.878*0.02±0.006**0.79±0.3226.40±10.19**0.03±0.008*0
6、.93±0.130TGF-β11.57±1.99*77.53±13.02**0.38±0.2149.63±6.31*195.85±85.1**0.24±0.152XiaoH,…LiaoYH,etal.CellImmunol.2009;260(1):51-5.芪苈强心改善AMI心肌的细胞因子蛋白表达(immunehistochemistrystaining)MIMI-QSTNF-αIL-10TGF-βXiaoH,…LiaoYH,etal.CellImmunol.2009;260(1):51-5.Immunehistochemistrystaining
7、showedcytokinesexpressioninthecardiacmyocytes*meansP＜0.05,comparewithSgroup;#meansP＜0.05,comparewithMIgroup芪苈强心改善AMI心肌的细胞因子蛋白表达(immunehistochemistrystaining)IOD/Area************######TheIOD/Areashowed: significantdifferenceofcytokinesexpressionbetweenMI&MI-QgroupsXiaoH,…LiaoYH
8、,etal.CellImmunol.2009;260(1):51-5.芪厉强心治疗改善AMI大鼠心功能芪厉强心治疗降低促炎
