坦索罗辛对输尿管下段结石治疗作用的临床研究

《坦索罗辛对输尿管下段结石治疗作用的临床研究》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。

1、坦索罗辛对输尿管下段结石治疗作用的临床研究2008暨南大学硕士学位论文中文摘要目的：评估a受体阻滞剂类药物??坦索罗辛作为输尿管下段结石的排石药物1的临床疗效。方法:203名输尿管下段结石患者随机分为2个治疗组。组1(对照组，100名)接受净石灵(1・5Tid)+消炎痛(25mgBid)治疗;组2(试验组,103名)接受坦索罗辛(0.4mgQd)+消炎痛(25mgBid)治疗。研究持续吋间至结石排出2或28天内。统计分析方法釆用independent-SamplesTTest、四格表资料的X检验、Cox回归分析及非

2、条件logistic回归分析。结果:两组排石率具有统计学差异。组1的排石率为62%(100名患者中有62名患者结石排出)，组2的排石率为79.6%(103名中有82名患者结石排出),P0.006o两组排石时间具有统计学差界。组1中62名患者排石平均时间为10.8天，组2中82名患者平均排石时间为8.51天,P0.000o两组患者中需要使用止痛药的例数具有显著性差异，组1为35名35%,组2为22名21.4%,P0.031o治疗期间，需进入急诊室或者入院治疗、误工时间、发生严重药物副反应等情况无统计学差异。生活质量评

3、分QOL两组间无显著性差异，但坦索罗辛治疗组的平均评分低于净石灵治疗组。结论:使用坦索罗辛可提高输尿管下段结石排石率,减少排石时间，且副反应的发生率低。临床使用坦索罗辛进行输尿管下段结石治疗具有良好的疗效。关键词：坦索罗辛；输尿管下段结石;药物排石T2008暨南大学硕士学位论文ABSTRACTObjective:Toassesstheclinicalefficacyoftheablocker?tamsulosininthe1medical-expulsivetherepyofdistalureterolithias

4、isMethods:Atotalof203patientswithstoneslocatedinthelowerureterjuxtavesicalorintramuraltractwereenrolledinthestudyandwererandowlydividedinto2groups.Group-1100patientsreceiveddailyoraltreatmentofJingshilingJiaonang(1.5Tid/day),Group-2receiveddailyoraltreatmentof

5、tamsuIosin(0.4mg/day)Thetreatmentperiodwas28daysforbothgroups.Statisticalanalyseswereperformedusingindependent-SamplesTTest>chi-squareTest^CoxRegressionmodelandindependentLogisticRegressionResults:Expulsionwasobservedin62of100patientsingroup-162%,82of103ingrou

6、p-279.6%.Thedifferenceingroup-1withrespecttogroup-2wassignificant,P0.006.Averageexpulsiontimeforgroup-1andgroup-2was10.8daysand8.51days.Astatisticalsignificantdifferencewasnotedinthetwogrouops,P0.000.Inthetreatmenttime,therewasnotsignifiedntdifferenceinthetwog

7、roupswithERvisitsandUrgenthospitalization^workdayslostanddurgsideeffects.TheQOLoftwogroupshavenotsignificantdifferenee,P0.06,buttheaveragevalueofgroup-2waslowerthangroup-lConclusion:Thetreatedwithanexpulsivemedicaltherapyinpatientswhenawatchfulwaitingapproachi

8、spossible-InourstudymedicaltreatmentswithtamsulosinprovedtobesafecindeffectiveasdemonstratedbythelowincidenceofsideeffectsandtheincreasedstoneexpulsionrateandreduceexpulsiontimesKe