固尔苏治疗早产儿肺透明膜病应用方法探讨

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1、固尔苏治疗早产儿肺透明膜病应用方法探讨【关键词】应用方法【摘要】目的通过应用固尔苏治疗早产儿肺透明膜病，探讨固尔苏的应用方法。方法将13例幽生后确诊新生儿肺透明膜病的早产儿随机分为两组，固尔苏（PS）常规方法组6例，改良方法组7例，患儿均为孕27〜35周，体重1200〜2600g,Ap-gar评分3〜10分，生后5〜lOmin入院的早产儿。结果患儿用药前均有不同程度的临床表现，女口：紫纽、窒息、呼吸暂停、低氧血症、胃液泡沫振荡试验（-）〜（土），胸片:肺泡膨胀不良或并存肺炎等。用药后改良方法组均较快改善缺氧症状，明显缩短双鼻道加压吸氧或持续低流量吸氧的时间以及住院时间，无1例死亡。常规方法组并

2、发气胸2例，两组比较,差异有显著性（P<0.05）o结论固尔苏治疗早产儿肺透明膜病改良方法组疗效显著，救治成功率高。关键词固尔苏早产儿肺透明膜病应用方法EffectsofCurosurfonthehyalinemembranediseaseofthepreterminfantsShiXiaoxiang,YiNanling,ZhouChuang,etal.DepartmentofPediatrics,theUlumuqiGeneralHospitalofLanzhouMilitaryRegion,Urumqi830000.[Abstract]ObjectiveTostudytheeffectso

3、fCurosurfonthehyalinemembranediseaseofthepreterminfants,moreover,toexploretheapplicationmethodsofCurosurf・MethodsTotallyl3preterminfantswererandomlydividedinto2groups,PStreatmentgroupof6cases,negativecontrolgroupof7cases.Allofthepatientswerepreterminfantswhowerepregnanted27~35weeks,Weightl200~2600g,

4、admittedtohospitalat5〜lOminutesafterbirth.ResultsBeforetheadministrationofCurosurf,allcasesofthe2groupshadvariousdegreesofclinicalmanifestations,suchascyanosis,as-phyxia,apnea,hypoxemia,foamtestofamnioticfluid(-~士,X-rayshowedvariouspulmonaryatelectasisorpneumo-nia,etal.Afteradministration,thecasesof

5、thetreatmentgroupsignificantlyimprovedtheirsymptomsandsignsofhypoxi-a,reducedthetimeofdirhinicpositivepressureoxygeninhalationorcontinuouslow-flowoxygeninhalation,cutdownthedaysofhospitalization,andnonewasdead.Whileinthecontrolgroup,leaseshadintracranialhemorrhage,8caseshadhypoxic-ischemicencephalop

6、athy,2casesdead,and2casesabandonedtherapybecauseoftheirserioussituations・Sig-nificantdifferencewasfoundbetweenthe2groups(P<0.05).ConclusionEffectsofCurosurfonthehyalinemem-branediseaseofthepreterminfantsareremarkable・WithCurosurf,weraisedtherescuerateofthehyalinemenbranedi-aeaseofthepreterminfantssi

7、gnificant!y.KeywordsCurosurfpreterminfantshyalinemembranedisease固尔苏即猪肺表面活性物质（PS）,应用于新生儿肺部疾病已有数十年历史。随着对PS的研究治疗的扩展及其应用方法的不断改进，固尔苏的疗效发挥愈充分。笔者应用固尔苏治疗13例早产儿肺透明膜病，改良方法组疗效显著。现总结如下。1资料和方法1.1一般资料本文采集病例为2000年5月