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1、十二指肠肿瘤58例外科诊断与治疗作者:倪启超,张春辉,沈洪薰,李一桔,王华,徐青作者单位:南通大学附属医院普外科,南通226001【摘要】冃的:提高十二指肠肿瘤的诊治水平。方法:对58例十二指肠肿瘤外科诊治的临床资料进行冋顾性分析。结果:(1)十二指肠肿瘤位于乳头上方4例,乳头周围50例,乳头卜'方4例;(2)临床表现随部位不同而不同,乳头上方肿瘤临床表现上腹部疼痛和呕叶,呕吐物胃内容,不含胆汁;乳头周围肿瘤临床表现为梗阻性黄疸,肤冃黄染伴不同程度上腹不适和不规则发热,可扪及肿大胆囊;乳头下方肿瘤临床表现上腹疼痛伴
2、呕吐,呕吐物为胃内容含胆汁,或呕血,黑便,可扪及肿块;(3)消化道气顿造影诊断正确率57.14%,B超35.9%,CT70.59%;纤维-1•二指肠镜为90.48%;⑷病理组织学诊断恶性肿瘤54例,其中十二指肠腺癌51例,包括十二指肠溃疡伴溃疡边缘癌变1例,乳头状腺瘤伴癌和局限性癌变各1例和十二指肠平滑肌肉瘤3例;乳头腺瘤2例;乳头壶腹部溃疡1例和乳头黏膜下腺癌样增生1例;(5)外科手术,胰十二指肠切除术50例,根治性胃十二指肠切除术4例,根治性十二指肠节段性切除术3例,经十二指肠乳头开口处肿瘤局部切除,胰胆管引流
3、术1例;(6)治疗结果:全组均治愈或好转出院,无手术死亡率;随访结杲,获随访21例,1年生存率66.67%,3年生存率42.86%,5年生存率33.33%o结论:纤维十二指肠镜检查和活检是诊断十二指肠肿瘤的主要方法;肿瘤部位不同,治疗方法亦异,乳头上方肿瘤以胃十二指肠切除为主,乳头下方肿瘤以十二指肠节段性切除为主,乳头周围肿瘤根据肿瘤生物学特性选择胰十二指肠切除或经-1•二指肠肿瘤局部切除(TDE)或ESEo【关键词】十二指肠肿瘤胃十二指肠切除术纤维十二指肠镜Surgerydiagnosisandtherapyof
4、58casesofduodenaltumorNIQichao,ZHANGChunhui,SHENHongxun,etal(DepartmentofGeneralSurgery,AffiliatedHospitalofNantongUniversity,Nantong226001)[Abstract]Objective:Toimprovethediagnosisandtherapyofduodenalturno匚Methods:Theretrospectiveanalysiswasmadeontheclinicali
5、nformationaboutthesurgicaltherapyof58casesofduodenaltumor.Results:(1)Amongthem,therewere4caseswiththetumorlocatedabovethepapilla,50aroundthepapillaand4belowthepapilla;(2)Theclinicalsyndromesdifferedduetothedifferentlocations・Thetumorsabovethepapillahadsuchsynd
6、romesasupperabdominalpainsandvomiting,butwithoutbile;thosearoundthepapillahadthesyndromesofobstructivejaundicefromskinandeyesaccompaniedbytheupperabdominalailmentandirregularfeverwhiletheenlargedgallbladderwaspalpable;andthosebelowthepapillahadthesyndromesofup
7、perabdominalpainsandvomitingwithbileorblood,andhadpalpablelumpsandblackstools;(3)Thecorrectnessofdiagnosisbywayofgastro-intestinalpneumaticbariumcontrastexaminationwas57.14%;thatofB-modeultrasonicscope35.9%;thatofCT70.59%;andthatofthefibropticduodenoscope90.48
8、%;(4)Diagnosedwithpatho-histologywere54casesofmalignanttumor(51casesoftheduodenaladenocarcinoma(AC),including1caseoftheduodenalulcerwithcancerouslesionsaround,1caseofmastoidadeno-t