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1、中医综介治疗方案治疗原发性中晩期肝癌的前瞻、随机、对照研究［摘耍］冃的：观察中医综合治疗方案治疗原发性中晚期肝癌的疗效。方法：采用前•瞻性、随机、平行对照实验的设计方法，97例患者分别用中医综合治疗一一中药鸦胆了汕介入治疗+内服川:积方+外敷癌理通(实验组，共49例)和西医治疗一一化疗药物灌注+碘汕栓塞+西药镇痛(对照组，共48例)治疗，观察两组患者的近远期疗效、毒副作用、镇痛起效时间、镇痛维持时间及患者牛•活质量变化。结果：两组疾病控制率的差界无统计学意义(P>0.05):与对照纽比较，实验纽毒副
2、作丿IJ发牛率明显降低(P〈0.05)；两纽镇痛起效时间无显著性差异(P>0.05)，镇痛维持时间分别为(10.37±2.18)h和(7.78±1.95)h,实验组明显优于对照组(1X0.01)；治疗后实验组卡氏评分优于对照组(P<0.05)；实验组中患者治疗后做体功能改善、症状减轻、总的生活质量较前提高，优丁对照组(P<0.05):治疗后3个月生存率两组比较差异无显著意义(P>0.05),但0.5、1年生存率，实验组分别为65.9%、3&6%,对照组分别为42.5%、18.1%,实验组优于西药对照
3、组(P<0.05)o两组患者的中位生存期分别为8.9个月和5.3个月。结论：中医综合治疗方案副作用低，并可延长镇痛维持吋间，提高患者牛活质量，改善远期生存，是治疗中晚期原发性肝癌的冇效方法。［关键词］肝癌；中医药疗法［中图分类号］R735.7［文献标识码］A［文章编号J1673-7210(2008)11(a)-017-05Prospectiverandomizedcontrolledstudyoncomplextreatmentoftraditionalchinesemedicinetoadvane
4、edprimaryhepatocarcinomaTTANHua-qin,LIANGGui-wen,HUANGXiao-qing,HUANGZhi-qing,LANGJiang-ming,ZHANGYu-ping,CHENXue-zhang,CHENYin-song(DepartmentofOncology,FoshanHospitalofTraditionalChineseMedicine,FoshanCity,GuangdongProvinee,Foshan528000,China)［Abstra
5、ct］Objective:Toobservetheeffectsofcomplextreatmentwithtraditionalchinesemedicineonadvancedprimaryhepatocarcinoma.Methods:97patientwithadvaneedprimaryhepatocarcinomawererandomlyandparallellydividedintoexperimentalgroupandcontrolgroup・Patientsinexperimen
6、talgroupweretreatedbycomplextreatmentwithtraditionalChinesemedicine,andpatientsincontrolgroupweretreatedbywesternmedicine.Thenthecurativeeffectofneartermandlongterm,thesideeffectandtoxicity,theonsettimeanddurationofanalgesiaaswellasthequantityoflife(QO
7、L)weredetermined.Results:Nosignificantdifferenceofdiseasecontrolratewasshownbetweenthetwogroups.Therateofsideeffectandtoxicityinoxperimentalgroupwaslowerthanthatincontrolgroup(P<0.05).Themeandurationofanalgesiaofexperimentalgroupwas(10.37±2.18)h,whichw
8、ashigherthanthatincontrolgroup(P<0.05),butnoconsiderabledifferenceoftheonsettimeofanalgesiawasshownbetweenthetwogroups.Karnofskyscoresofexperimentalgroupwashigherthanthatincontrolgroupaftertreatment(P<0.05).Afterthetreatment,thepatients
