资源描述：
《临床医学论文-益气散聚方治疗非酒精性脂肪性肝病随机对照临床试验》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、临床医学论文•益气散聚方治疗非酒精性脂肪性肝病随机对照临床试验作者：娄少颖，刘毅，马宇浊，陈海英，陈伟华，应健，何燕铭，王文健【摘要】目的：观察中药益气散聚方对非酒精性脂肪性肝病(nonalcoholicfattyliverdisease,NAFLD)患者的疗效。方法：将符合纳入标准的67例NAFLD患者，随机分为益气散聚方组39例和安慰剂对照组28例。分别予益气散聚方和安慰剂治疗3个月，观察治疗前后临床症状、肝脾CT比值、体质量指数(bodymassindex,BMI)、腰围、稳态模型胰岛索抵抗指数(homeostaticmodelassessmentforin
2、sulinresistance,H0MA2IR)>肝功能、肿瘤坏死因子a(tumornecrosisfactora,TNFa)、高敏C反应蛋口(highsensitivityCreactiveprotein,hsCRP)和血脂等方面的变化。结果：治疗后，益气散聚方组临床症状明显缓解，肝脾CT比值明显上升，BMhH0MA2IR水平下降，肝功能好转，TNFa、hsCRP和血脂水平明显下降，与安慰剂组相比，差异有统计学意义；益气散聚方组总有效率为94.87%。结论：中药益气散聚方治疗NAFLD疗效确切。【关键词】脂肪肝益气散聚颗粒螺旋CT检查胰岛素抵抗随机对照试验Obj
3、ective:ToobservethetherapeuticeffectsofYiqiSanjuFormula(YQSJF),acompoundtraditionalChineseherbalmedicine,intreatmentofnonalcoholicfattyliverdisease(NAFLD).Methods:SixtysevenpatientsdiagnosedwithNAFLDwererandomlydividedintotwogroups:YQSJFtreatedgroup(39cases)andplacebogroup(28cases)・Th
4、eNAFLDpatientsinthetwogroupsweretreatedwithYQSJFandplaceborespectivelyfor3months.Clinicalsymptoms,theCTratioofliverspleen,bodymassindex(BMI),waistcircumference,homeostaticmodelassessmentforinsulinresistance(H0MA2IR)andthelevelsofalanineaminotransferase(ALT),aspartateaminotransferase(A
5、ST),tumornecrosisfactora(TNFa),highsensitivityCreactiveprotein(hsCRP),triglyceride(TG),totalcholesterol(TC),highdensity1ipoprotein(HDL)andlowdensity1ipoprotein(LDL)wereevaluatedbeforeandaftertreatment・Results:Aftertreatment,theclinicalsymptomswereimprovedandthelevelsofBMI,waistcircumf
6、erence,H0MA2IR,ALT,AST,TGandTCweredecreasedsignificantlyintheYQSJFtreatedgroup(P<0・05)・TheCTratioofliverspleenintheYQSJFtreatedgroupwasincreasedsignificantlyascomparedwiththeplacebogroup(P<0.01).Conclusion:YQSJFhasreliableanddefinitetherapeuticeffectsonNAFLD.Keywords:fattyliver;YiqiSa
7、njuFormula;spiralCT;insulinresistence;ranomizedcontrolledtrials非酒精性脂肪性肝病(nonalcoholicfattyliverdisease,NAFLD)是指除外酒精和其它明确的肝损伤因素所致的，以弥漫性肝细胞大泡性脂肪变为主要特征的临床病理综合征［1］,其病理机制与朕岛素抵抗(insulinresistance,IR)和遗传易感性等因素冇关［2］。近年来由于生活水平的捉高和饮食结构的改变，NAFLD发病率呈明显上升趋势。临床上我们应用益气散聚方治疗NAFLD,在改善肝功能，调节血脂，减少肝脏脂肪浸润
8、和提高肝脾
