CAC-MISC 5-1993 GLOSSARY OF TERMS AND DEFINITIONS Residues of Veterinary Drugs in Foods-国际食品法典委员会标准-CAC

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1、CAC/MISC5-1993Page1of4GLOSSARYOFTERMSANDDEFINITIONS(ResiduesofVeterinaryDrugsinFoods)(CAC/MISC5-1993,Amended2003)FOREWORDTheGlossaryofTermsandDefinitionshasbeenelaboratedbytheCodexCommitteeonResiduesofVeterinaryDrugsinFoods(CCRVDF)withaviewtowardsprovidinginformatio

2、nandguidancetotheCommittee,andisintendedforinternalCodexuseonly.TheGlossaryisintendedtobeanopenlistwhichissubjecttoreviewbytheCCRVDFinordertoupdate,modifyoraddtothelistofterms.RelevanttermselaboratedbyotherCodexCommitteesareincluded.AttentionisdrawntotheNotesfollowi

3、ng.1.AcceptableDailyIntake(ADI):AnestimatebyJECFAoftheamountofaveterinarydrug,expressedonabodyweightbasis,thatcanbeingesteddailyoveralifetimewithoutappreciablehealthrisk(standardman=60kg)(SeeNote3).2.BioavailableResidues:Thoseresiduesthatcanbeshown,bymeansofanapprop

4、riatemethod(e.g.Gallo-Torresmethod)tobeabsorbedintosystemiccirculationwhenfedtolaboratoryanimals(SeeNote3).3.BoundResidue:Residuesderivedfromthecovalentbindingoftheparentdrugorametaboliteofthedrugandacellularbiologicalsolubleorinsolublemacromolecule.Theseresiduesare

5、notextractablefromthemacromoleculebyexhaustiveextraction,denaturationorsolubilizationtechniques.Theydonotresultfromtheincorporationofmetabolized,radiolabelledfragmentsofthedrugintoendogenouscompounds,orthesamemacromoleculebynormalbiosyntheticpathways.Informationconc

6、erningthecalculationofboundresiduesmaybefoundinAnnex3thofthe34ReportofJECFA(pages58-61,WHOTRS788).4.Egg1Thefreshedibleportionofthespheroidbodyproducedbyfemalebirds,especiallydomesticfowl.PortionofthecommoditytowhichtheMRLapplies:Theedibleportionoftheeggincludingthey

7、olkandeggwhiteafterremovaloftheshell5.ExtractableResidue:Thoseresiduesextractedfromtissuesorbiologicalfluidsbymeansofaqueousacidicorbasicmedia,organicsolventsand/orhydrolysiswithenzymes(e.g.sulfataseorglucuronidase)tohydrolyzeconjugates.Theextractionconditionsmustbe

8、suchthatthecompoundsofinterestarenotdestroyed(SeeNote2).16.Fat:Thelipid-basedtissuethatistrimmablefromananimalcarcassorcutsfromananimalcar