匹维溴铵联合谷维素治疗老年肠易激综合征临床疗效观察

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1、匹维澳钱联介谷维索治疗老年肠易激综介征临床疗效观察作者单位：553028贵州省六盘水市首钢水钢总医院通讯作者：顾红【摘要】F1的探讨匹维滉镀联合谷维素治疗老年肠易激综合征的临床疗效。方法将73例老年肠易激综合征患者随机分为试验组537例)和対照组536例)。试验组给予匹维澳钱治疗，3次/d,每次50mg,另给予谷维索治疗，3次/d,每次30mgo对照组只给了匹维漠镀治疗，3次/d,每次50mgo两组均以30d为1个疗程，评估两组的临床治疗效果。结果试验组和对照组的显效率分别62.3%和27.8%,两组比较差异冇统计学意义(x^2<

2、/sup>6.37,P<0・05)。试验组和对照组的总有效率分别89.2%和61.1%,两组比较差异亦有统计学意义(x^{2〈/sup>7.45,P<0.05)o两组均未出现明显不良反应，患者耐受性好。结论匹维渙钱联合谷维索治疗老年肠易激综合征疗效明显，不良反应轻微，值得临床推广。【关键词】匹维漠鞍；谷维素；肠易激综合征Investigationofpinaverinmbromidecombinedwithoryzanolinthetreatmentofolderpatientswithirritablebowe1syndromeG}

3、UHong,LTYong-kang,LTHui,WANGLin,LTMei-xing.LiupanshuiShougangSteelWaterGeneralHospital,Liupanshui553028,China[Abstract]ObjectiveToinvestigateclinicalefficacyofpinaverinmbromidecombincdwithoryzanolinthetreatmentofolderpatientswithirritablebowelsyndrome.MethodsSeventy-three

4、olderpatientswithirritablebowelsyndrome(RomeIIdiagnosticcriteriaforfunctionalboweldisorders)wererandomlydividedintotwogroups:testgroup(n37)andcontrolgroup(n36).Controlgroupweregivenpinaveriumbromidetreatment,threetimesaday,eachtime50mg.Testgroupweretreatedonthebasisofanot

5、hergivenoryzanoltreatmentthreetimesaday,eachtime30mg・Onecycleinclude30days,observedtheclinicaleffect・ResultsTheeffectiverateofthetestgroupandcontrolgroupwere64.5%and26・7%,respectively,thereweresignificantdifferencesbetweenthetwogroups(x²6・37,P<0.05)•Thetotaleff

6、ectiverateoftestgroupandcontrolgroupwere64・5%and26.7%,respectively,thereweresignificantdifferencesbetweenthetwogroups(x²7.45,P<0.05).ConclusionOryzanolpluspinaveriumbromideinthetreatmentofolderpatientswithirritablebowe1syndromehasbetterclinicalefficacy,mildadve

7、rsereactions,itisworthyofpromotion.[Keywords]Pinaveriumbromide;Oryzanol;Irritablebowelsyndrome肠易激综合征(irritablebowe1syndrome,IBS)是一种临床上常见的胃肠功能紊乱性疾病。临床主要表现为腹痛、腹胀、排便习惯的改变(腹泻、便秘)和人便性状异常(稀便、黏液便、硬节便)，而缺乏特界形态学、牛化改变。其是由多因素引起、以肠道症状为主的界质性疾病^[1〜3]。肠易激综合征的病因和发病机制复杂，临床上缺乏标准的

8、治疗方法，目前还主要限于经验性的对症处理^[4〜5]o一些患者常规药物治疗无效，症状迁延不愈，频繁就诊，严重影响牛活质量，经济费用较高。IBS患者常伴有明显心理障碍。和关症