肝内胆管结石病胆管上皮细胞pcna和bcl-2的表达及意义

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1、目的：通过检测重常腓肉腿警、胖肉腿簪錨右病釉虺管癌三种魁聲纯织申虺管土:缁施的PCNA和Bel二2蛋自義逵，探讨胖肉胆營绪右病胆管圭厦甦吾荐程癌变趋势。S'看滦：应禺嵬疫麵织他爭S二P漬対49厠萍肉M«病釉16例胆管癌齣苕轄纨织韧片及10例止常辭内IS管细织建荷PCNA釉Bel-2染亀,检测PCNA釉Bc「2蛋倉袤运，统计势祈能较宜徊辺厨飾愛列。结杲：1•程49例肝内胆管结着病申胆管星菲輿型增生7俐，占14.29%,星现為慢性增殖性駁管炎，其特征性病瑾敢变是管腔r账,胆管壁和管璧周圉组织显著纤维

2、他，纳馳层次增爹,捧列棗乱,核莢探變，體管璧棘營壁稠圃绸织看炎瘻绸胞浸液h胆管癌的组织学敢愛均捌腺癌，其申离翁他腺癌10傥(62.5%),中分値腺癌4例(25%),低分他腺癌2例(12.5%)。2.PCNA釉BCL-2蛋自的養迭程匪常51簷

3、2.48,鲁组闾PCNA和BCL-2蛋自表逵差歸经统计縈翁析鞫蒲矍著意发(P<0・05)。3.PCNA的義述餐鼾肉麒管结看病膻營垒囊輾理曙生齟(52.04主11.35)与高管癌细(66.20圭6・96)之闾的羞畀无统计学意义，P>0・05。4.PCNA科IBel-2蛋自飽霰迭餐舎葬黄疸的卿肉迪管绪霸病憩者的虺管土:细砲中(40.05主10.91、17.55主11.37)明显高手苑黄疸詢卿內腕管绩有病患者(30.17圭10.66、10.80±6.94),P<0・05°5•胆管癌申PCNA的義运隨势

4、他程度不同而芥同，高分他组(68.55圭7.75),申分他组(81.63圭2・52)和低翁偲组(88.73*0.71)BSWPCNA義逝墓异经统许学势栃蓿显薯羞异（P〈0・05）。6.Bel二2餐不風势他穆慶附

5、£管癱申養迭苏同，喬勢他胆管癌姐（53.00圭4.72）購龜高手申翁他细（29.07主5.58）额低詹他魁管癩细（31.22主4.10)(P<0.05)o7.PCNA表逵莓Bel-2蛋自的袤逵律窪相羡性，Pearson狷笑篥数值^0.764,P<0.01o结枪：1•辭内•2二:缮看病恿者

6、的腿管垒厦宥鹅蜃翳形愛。其中非輿型增笔的葬形变昼著，蒋恶变趙势。2.睿养黄疸館腓肉虺管錨醤病恿蕭是腿曹生陵绷勉莽彤变舸鬲危圍熱3.PCNA釉Bel-2蛋自惡透高低与胆管曆的翁怨穆度密物棘義。笑键阖：脐肉胆管结着病胆管癌非興型增生兔疫鲍织他学PCNABel-2AbstractObjective:Hepatolithiasisisariskfactorforcholangiocarcinoma.However,itisdifficulttoidentifyearlycholangiocarcinom

7、athatoccursasacomplicationofhepatolithiasis.Toinvestigatetherelationshipbe札eenhepatolithiasisandcho1angiocarcinoma,theexpressionofPCNAandBcl-2werestudiedinnonnalbiliaryepithelium,bileductepithelialcellsinpatientswithhepatolithiasisandcholangiocarcino

8、ma.Methods：TheexpressionofPCNAandBel二2weredetectedin49casesofhepatolithiasisparaffinspecimenusingS-Pimmunohistochemicalstaining,16casesofcholangiocarcinomaand10casesofnormalbiliaryepitheliumparaffinspecimenwerecollectedascontroLAditionally,theexperim

9、entaldatawereanalysedbystatistic.Results:1.Atypicalepithelialhyperplasiawasfoundin7of49cases(14.3%)withhepatolithiasis,thebileductsdemonstratedluminaldilationandpronouncedfibrosisofductalwallsandperiductaltissueshfetologically.Therewasinflaffiiatoryc