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1、者差异无统计学意义(D0.05),儿童CKD2-5期患者各组间差异均有统计学意义(PV0.05)。因此表明随着肾功能不全的逐渐加重，儿童CKD患者肾实质平均杨氏模量值呈递增的趋势。儿童CKD2・5期患者肾实质平均杨氏模量值与患者血清肌肝值有较好的相关性,相关系数(r)为:0.93(PV0.01)。3.SWE技术定量分析儿童CKD肾实质的ROC曲线下面积(AreaUndertheROCCure,AUC)为0.83,平均杨氏模量值鉴别CKD组与正常对照组有统计学意义(PvO.05),AUC的95%可信区间为(0.93,0.98)。Youden指数最大值为0.8
2、1,该点所对应的平均杨氏模量值为4.47Kpa,以此作为儿童CKD肾实质的平均杨氏模量值参考值时，SWE诊断的敏感度、特异度分别为：86.8%、94.7%o结论：剪切波弹性成像能获得各种形态的肾脏图像，并且重复性好，其量化数据客观的反映组织的软硬度，在一定程度上反映了组织病理特点，量化的弹性信息，对评估儿童CKD患者肾实质病变程度提供有价值参考。关键词：超声检查儿童慢性肾病剪切波弹性成像AssessmentofChronicKidneyDiseasewithQuantitativeShare-waveElasticityImagingPostgraduat
3、e:ShuhuaWuSupervisor:Prof.RuifangZhangDepartmentofUltrasoundTheFirstAffiliatedHospitalofZhengzhouUniversityZhengzhou,China450052AbstractBackgroundandobjectiveChronickidneystructureandfunctionofthevariouscausesofdisorders,suchaschronicglomerulonephritis,nephroticsyndrome,hypertensi
4、on,diabetes,causedbymorethanthreemonths,knownaschronickidneydisease.Inrecentyears,theglobalincidenceofCKDshowedanincreasingtrend,CKJDaccountingforfifthplacetoninthplaceinthemaincausesofdeathinhumans,CKDifnotwellcontrolled,thedestructionofrenaltissuewillgraduallyincrease,renalfunct
5、ionwillcontinuetodeteriorateandeventuallydevelopedintouremia,Therefore,earlychildhoodCKDdetection,earlydiagnosisofchildhoodCKDpatientswithearlytreatment,candelaytheprogressionofthediseaseinpatients,slowingtherateofdeteriorationofrenalfunction,cangreatlyimprovethequalityoflifeofpat
6、ients,delayESRD(End-stagerenaldisease,ESRD)dialysis-dependentrenaltransplantationtreatment,hasaveryimportantsignificance.ForthepastultrasoundforthediagnosisofCKDmulti-usetwo-dimensionalultrasound,colorDopplerultrasoundtechnology,butthesetechniqueshavecertainpersonalsubjectivityand
7、onthebloodflowhasobviousangledependence・ElastographytechnologyinrecentyearsprovidesavaluablenewtoolforfurtherstudyofchildrenwithCKD,thehardnessofwhichShear-waveelasticityimaging(Share-waveelasticityimaging,SWE)quantitativelyanalyzedusinganalyticaltechniquestomeasuretissueandYoungs
8、modulus(Youngfsmodulus)toreflectt
