129例iga肾病临床与病理分析内科学(肾脏)专业毕业论文

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1、中英文对照词表IgA肾病ImmunoglobulinAnephropathy(IgAN)肾活检Renalbiopsy血尿Hematuria蛋白尿Proteinuria系膜增生性肾小球肾炎Mesangialproliferativeglomeru1onephritis小管间质病变Tubularinterstitiallesion肾病综合征Nephroticsyndrome肾炎综合征Nephriticsyndrome局灶性节段性增生Focal-segmentalproliferation硬化Sclerosis新月体形成Formationofcresc

2、ent小管萎缩Tubularatrophy终末期肾病End-stagerenaldisease(ESRD)慢性肾衰竭Chronicrenalfailure129例IgA肾病临床与病理分析研究生杨胜樺导师杨亦彬中文摘要【目的】观察和分析青少年和成人IgA肾病的病理改变与临床特点。【方法】选择我院2003年5月至2007年6月间，经肾活检免疫病理证实的129例原发性IgA肾病，按不同年龄分为青少年组和成人组，对其临床表现及组织学特点进行比较和分析。【结果】IgA肾病占同期肾活检病例的32.8%。青少年组以血尿和/或蛋白尿为主要临床表现(7&6%),出

3、现高血压和功能损害的较少，病理表现以肾小球轻微病变和系膜增生性肾小球肾炎为主，小管间质病变相对较轻；成人组表现为肾病综合征及肾炎综合征的患者所占比例较大(60.9%),常伴有高血压和肾功能不全，病理表现以弥漫性系膜增生、局灶节段增生.硬化、新月体形成为主，可见间质炎性细胞浸润、小管萎缩。【结论】IgA肾病在青少年和成人之间存在某些不同的临床和病理学特点，其临床表现可能与病理损害程度有一定的关系。【关键词】IgA肾病；病理学；临床表现Clinicalpresentationandpathologicalfeatureof129caseswithIg

4、AnephropathydiagnosedbyrenalbiopsyPostgraduateyangshengfengTutoryangyibinAbstractObjective:ToinvestigatetheclinicalandpathologicalfeatureofpatientswithIgAnephropathy(IgAN)between・adolescentsandadults.Methods：FromMay2003toJune2007were129patientswithIgANthathadbeenconfirmedbypa

5、thologydividedinto■adolescent(n=42)andadult(n=87)groups.Theirclinicalmanifestationandpathologicalfeaturewereanalyzed:retrespectively.ResuIts：IgANwasfound32.8%inallrenalbiopsycasesforthesameperiod.Allcasesillustratedmesangialcellsandmatrixproliferationindifferentdegree・Inadole

6、scents,hematuriaand/orproteinuriaweremainlyclinicalpresentation(78.6%),whilehypertensionandrenalfunctionlesionwerenotcommon.Pathologicalchangepresentedmainlyminimalglomerularlesion,mesangialcellsandmatrixproliferation,andmildtubularinterstitiallesion・Inadults,nephroticsyndrom

7、eandnephriticsyndromewerepredominantlyclinicalmanifestation(60・9%),hypertensionandrenalinsufficiencywererelativelycommon.Majorpathologicalchangewerediffusemesangialcellsandmatrixproliferation,focalsegmentalproliferation,sclerosis,formationofcrescent,interstitialinflammatoryce

8、llinfiltrationandtubularatrophy.Conclusion：Therearesomedifferentpres