793例iga肾病临床与病理分析

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1、万方数据(CRF)(82，10．3％)．Amongthem，U-abwasthemostcommon(41．2％)；R—GHwasyoungerthantotalcases(尸<0．01，28．9±10．2VS．32．9±12．1year)whileCRFwasolder(P<0．01，37．7±13．4VS．32．9±12．1)；I．HandR—GHweremorecommonlyoccurredinfemale(尸<0．01，1：3．46VS．1：1．27and1：2．39VS．1：1．27，res．)whileMP

2、andCRFinmale(尸<0．05，尸<0．01，l：0．87VS。1：1．27and1：0．58VS．1：1．27，res．)．(4)40．4％，37．5％and33．9％ofthecasespresentedwithhigherleveloftotalcholestero(CHOL)andtriglyceride(TG)andlowlevelofserumalbumin．26．2％ofthepatientshadincreasedlevelofserumuricacid(UA)andpartofthecasesw

3、ithincreasedlevelsofserumcreatinine(Scr)andbloodureanitrogen(BUN)．MostofcaseshadnormallevelsofserumIgGIgAandC4，while35．1％presentedwithlowerserumC3．Urinaryfindingsshowedmostofpatientspresentedwithhematuriaand／orproteinuria．2．Pathologicaldataof793caseswithIgAN(1)Ac

4、cordingtoWHOdefinition，themostfrequenthistologicalpattemofglomerularinjurywasfocaland／orsegmentalglomerulosclerosis(FSGS)，foundin57．4％ofpatients．ByusingOxfordClassification，themostcommonpathologydiagnosiswasMOS1EOT0(25．6％)，ofwhichsegmentalglomerularsclerosis(S1)a

5、ccountedfor58．O1％．Allthecasespresentedwithmesangialcellproliferationandmildproliferationwasthemostcommon．79．8％、86．1％and84．9％ofthecasespresentedwithglomerulosclerosis，interstitialfibrosisandtubularatrophyrespectively,mostofthecaseswithrenalinterstitialinflammation

6、(76．4％)andvasculopathy(58．9％)，whilepartofthecaseswithcrescentformation(21．8％)，capsularadhesion(11．1％)andpericapsularfibrosisVII万方数据(14．4％、)．(2)Of793patients，thedistributionofimmunofluorescencewasA，AGAM，andAGMin384(48．4％)，128(16．1％)，200(25．2％)and81(10．2％)patientsr

7、espectively．TherangeofIgAfluorescenceintensitywasfrom+to++++andIgA++wasthemostcommon(48．4％)．Inaddition，44．5％ofthewholecaseswithcomplementdeposition，ofwhichC3depositonwasthemostcommon(95．7％、)．3．Relationshipbetweenclinicalindicatorsandpathologicalfeatures(1)Accordi

8、ngtoOxfordClassification，thelevelsofmeanarterialpressure(MAP)andUAwereincreasedofmesangialcellproliferarionM1thanM0(尸