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《138例iga肾病病理分型与临床分析》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、78一ChinJLabDiagn,January,2014,Vol18,No.1文章编号:1007—4287(2014)01—0078—03138例IgA肾病病理分型与临床分析侯媛媛,张立,苏森森,刘金瑞,邹洪斌(吉林大学白求恩第一医院肾病科,吉林长春130021)摘要:目的探讨不同IgA肾病病理分级与临床特征间的关系。方法回顾性分析138例经肾活检病理确诊为IgA肾病的病理资料,系统分析各个病理分级之间的关系及病理分级与年龄、血白蛋白、24小时尿蛋白定量、尿素氮、血肌酐、血红蛋白、c3、C4、IgA、IgA/C3、IgM、IgG、胆固醇、甘油三酯、低密度胆固醇、高密度胆固
2、醇等临床表现之间的相互关系。结果病理分型中I级占5.80,1I级占18.84,Ⅲ级占5O.()(],Ⅳ级占21.74,V级占3.62。病理分型以Ⅲ级较为多见;IgA肾病病理分级之问血肌酐有非常显著性差异(PO.05)。结论IgA肾病病理表现多样性,与临床各实验室指标具有不平行性,早期行肾活检明确病理类型有助于指导治疗及判断预后。关键词:IgA肾病;临床表现;病理中图分类号:R692文献标识码:AIgAnephropathypathologyclassificationandclini
3、calanalysis0f138casesHOUYuan—yuan,ZHANGLi,SUSen—sen,eta1.(Deparmentofnephrology,BethuneFirstHospital,JilinUniversity,Changchun130021,China)Abstract:ObjectiveDiscusstherelationshipbetweendifferentIgAnephropathypathologicalgradingandclinicalfeature's.MethodsRetrospectiveanalysisof138casesoft
4、heIgAnephropathypathologicaldataswhichwerediag—nosedbyrenalbiopsypathology,Systematicanalysisoftherelationshipbetweenthevariouspathologicstageandthere—lationshipbetweenthepathologicstageandtheclinicalmanifestation,suchasage,24hoursurinaryprotein,bloodalbu—minquantitative,ureanitrogen,serum
5、creatinine,hemoglobin,C3,C4andIgA,IgA/C3,IgMandIgG,cholesterol,tri—glyceride,lowdensitycholesterol,HDLcholesterol,etc.ResultsPathologicaltypeofClassIaccountedfor5.80,1Iclassaccounted18.84,lIgradeaccounted50.00,IVclassaccounted21.74,Vclassaccountingfor3.62.Path—ologicaltypeofClass1Imorethan
6、others;ThepathologicalgradingofIgAhasobvioussignificantdifferencewithser—Hmcreatinine(P<0.01),buthasnosignificantcorrelationWithage,serumalbumin,bloodureanitrogen,C4,IgA,IgM,I.DLcholesterol(P>O.05).ConclusionIgAnephropathypathologicalmanifestationsarediversityandhavenotparalleltOeachindexo
7、fclinicallaboratoryparameters,Clearlypathologicaltypebyearlyrenalbiopsyhelpsguidetreat—mentandprognosis.Keywords:IgAnephropathy;clinicalmanifestation;pathology(ChinJLabDiagn,2Ol4,18:0078)IgA肾病(IgAN),又称Berger病,是一种以床各个指标间的关系,探讨不同IgA肾病的临床和IgA为主的免疫球蛋白沉积在肾小球系膜区为主要病
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