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1、LymphomaZhongshanHospital,FudanUniversityZouShanhuaDefinition：AgroupofneoplasticdiseasesoflymphoidtissuesClassification：Hodgkin′sDisease,HD(Hodgkin′sLymphoma)NonHodgkin′sLymphoma,NHL)GeneralConsiderationsClinicalFeatures：Painless,progressivelymphadenectasisFev
2、er,weightloss,nightsweat；cachexiaHepatosplenomegalyEpidemiology：Incidence：incities/inthecountry;male/female;ageHD8～11％；NHL90%GeneralConsiderationsVirulogy:EBvirus→Burkittlymphoma,HDHumanT-cellLymphotropicVirustype1,HTLV-1→AdultT-celllymphoma/leukemia,ATLHTLV-2
3、→MycosisFungoidesHelicobacterPylori→MALTlymphomaKaposisarcoma-associatedherpesvirus→primarybodycavitylymphomaEtiologyandPathogenesisImmuneStatesofHost：Immunodeficiency/immunosuppressionMechanism：Antigenicstimulation→lymphadenosis(modulation↓)→infiniteprolifera
4、tion→lymphomaEtiologyandPathogenesisClassificationofLymphomaHD：Reed-Sternberg(R-S)CellClassificationofLymphomaRyeClassification，1966LymphocytepredominanceNodularsclerosisMixedcellularityLymphocytedepletionClassificationofLymphomaWHOClassification,2001Nodularly
5、mphocytepredominanceHodgkin'slymphomaClassicalHodgkin'slymphomaLymphocyte-richclassicalHodgkin'slymphomaNodularsclerosisHodgkin'slymphomaMixedcellularityHodgkin'slymphomaLymphocytedepletionHodgkin'slymphomaClassificationofLymphomaNHL：ClassificationofLymphomaNH
6、L：IWF，1982REAL，1994WHO，2001WorkingFormulationLow-gradelymphomaA.smalllymphocytic,consistentwithchroniclymphocyticleukemiaplasmacytoidB.follicular,predominantlysmallcleavedcelldiffuseareassclerosisC.follicular,mixedsmallcleavedandlargecelldiffuseareassclerosisW
7、orkingFormulationIntermediate-gradlymphomaD.follicular,predominantlylargecelldiffuseareassclerosisE.diffuse,smallcleavedcellsclerosisF.diffuse,mixedsmallandlargecellsclerosisepithelioidcellcomponentG.diffuse,largecellcleavedcellnoncleavedcellsclerosisWorkingFo
8、rmulationHigh-gradelymphomaH.mmunoblastic,largecellplasmacytoidclearcellpolymorphousepithelioidcellcomponentI.lymphoblastic,convolutedornonconvolutedcellJ.smallnoncleavedcell,Burki
