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1、内科学-淋巴瘤-邹善华Definition:AgroupofneoplasticdiseasesoflymphoidtissuesClassification:Hodgkin′sDisease,HD(Hodgkin′sLymphoma)NonHodgkin′sLymphoma,NHL)GeneralConsiderationsClinicalFeatures:Painless,progressivelymphadenectasisFever,weightloss,nightsweat;cachexiaHepatosplenomegalyEpidemiology
2、:Incidence:incities/inthecountry;male/female;ageHD8~11%;NHL90%GeneralConsiderationsClassificationofLymphomaRyeClassification,1966LymphocytepredominanceNodularsclerosisMixedcellularityLymphocytedepletionClassificationofLymphomaWHOClassification,2001NodularlymphocytepredominanceHodgki
3、n'slymphomaClassicalHodgkin'slymphomaLymphocyte-richclassicalHodgkin'slymphomaNodularsclerosisHodgkin'slymphomaMixedcellularityHodgkin'slymphomaLymphocytedepletionHodgkin'slymphomaClassificationofLymphomaNHL:ClassificationofLymphomaNHL:IWF,1982REAL,1994WHO,2001WorkingFormulationLow-
4、gradelymphomaA.smalllymphocytic,consistentwithchroniclymphocyticleukemiaplasmacytoidB.follicular,predominantlysmallcleavedcelldiffuseareassclerosisC.follicular,mixedsmallcleavedandlargecelldiffuseareassclerosisWorkingFormulationIntermediate-gradlymphomaD.follicular,predominantlylarg
5、ecelldiffuseareassclerosisE.diffuse,smallcleavedcellsclerosisF.diffuse,mixedsmallandlargecellsclerosisepithelioidcellcomponentG.diffuse,largecellcleavedcellnoncleavedcellsclerosisWorkingFormulationHigh-gradelymphomaH.mmunoblastic,largecellplasmacytoidclearcellpolymorphousepithelioid
6、cellcomponentI.lymphoblastic,convolutedornonconvolutedcellJ.smallnoncleavedcell,Burkitt'sornon-Burkitt'sWorkingFormulationMiscellaneouscompositemycosisfungoideshistiocyticextramedullaryplasmacytomaunclassifiableotherREALClassificationB-cellneoplasmsI.PrecursorB-cellneoplasm:precurso
7、rB-lymphoblasticleukemia/lymphomaII.PeripheralB-cellneoplasmsA.B-cellchroniclymphocyticleukemia/prolymphocyticleukemia/smalllymphocyticlymphomaB.Lymphoplasmacytoidlymphoma/immunocytomaC.MantlecelllymphomaD.Folliclecentercelllymphoma,follicular1.Provisionalcytologicgrades:Ismallcell,
8、IImixedsmallandlarg