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1、LymphomaZhongshanHospital,FudanUniversity ZouShanhuaDefinition：AgroupofneoplasticdiseasesoflymphoidtissuesClassification：Hodgkin′sDisease,HD(Hodgkin′sLymphoma)NonHodgkin′sLymphoma,NHL)GeneralConsiderationsClinicalFeatures：Painless,progressivelymphadenectasisFever,weightloss,nightswea
2、t；cachexiaHepatosplenomegalyEpidemiology：Incidence：incities/inthecountry;male/female;ageHD8～11％；NHL90%GeneralConsiderationsVirulogy:EBvirus→Burkittlymphoma,HDHumanT-cellLymphotropicVirustype1,HTLV-1→AdultT-celllymphoma/leukemia,ATLHTLV-2→MycosisFungoidesHelicobacterPylori→MALTlymphom
3、aKaposisarcoma-associatedherpesvirus→primarybodycavitylymphomaEtiologyandPathogenesisImmuneStatesofHost：Immunodeficiency/immunosuppressionMechanism：Antigenicstimulation→lymphadenosis(modulation↓)→infiniteproliferation→lymphomaEtiologyandPathogenesisClassificationofLymphomaHD：Reed-Ste
4、rnberg(R-S)CellClassificationofLymphomaRyeClassification，1966LymphocytepredominanceNodularsclerosisMixedcellularityLymphocytedepletionClassificationofLymphomaWHOClassification,2001NodularlymphocytepredominanceHodgkin'slymphomaClassicalHodgkin'slymphomaLymphocyte-richclassicalHodgkin'
5、slymphomaNodularsclerosisHodgkin'slymphomaMixedcellularityHodgkin'slymphomaLymphocytedepletionHodgkin'slymphomaClassificationofLymphomaNHL：ClassificationofLymphomaNHL：IWF，1982REAL，1994WHO，2001WorkingFormulationLow-gradelymphomaA.smalllymphocytic,consistentwithchroniclymphocyticleukem
6、iaplasmacytoidB.follicular,predominantlysmallcleavedcelldiffuseareassclerosisC.follicular,mixedsmallcleavedandlargecelldiffuseareassclerosisWorkingFormulationIntermediate-gradlymphomaD.follicular,predominantlylargecelldiffuseareassclerosisE.diffuse,smallcleavedcellsclerosisF.diffuse,
7、mixedsmallandlargecellsclerosisepithelioidcellcomponentG.diffuse,largecellcleavedcellnoncleavedcellsclerosisWorkingFormulationHigh-gradelymphomaH.mmunoblastic,largecellplasmacytoidclearcellpolymorphousepithelioidcellcomponentI.lymphoblastic,convolutedornonconvolutedcellJ.smallnonclea
8、vedcell,Burk
