资源描述：
《FICLIL-2基因RS785 1696多态性相关 Delayed Graft功能与肾脏急性排斥反应 同种异体移植受者》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Arch.Immunol.Ther.Exp.(2018)66:65–72https://doi.org/10.1007/s00005-017-0475-5ORIGINALARTICLEFicolin-2Geners7851696PolymorphismisAssociatedwithDelayedGraftFunctionandAcuteRejectioninKidneyAllograftRecipients121,2EwaDabrowska-Zamojcin•MichalCzerewaty•DamianMalinowski•2
2、23MaciejTarnowski•SylwiaSłuczanowska-Głabowska•LeszekDomanski•42KrzysztofSafranow•AndrzejPawlikReceived:9February2017/Accepted:6April2017/Publishedonline:23May2017ÓTheAuthor(s)2017.ThisarticleisanopenaccesspublicationAbstractFicolin-2isanactivatorofthecomplementsigni
3、ficantlyhigherinpatientswithAR(TvsGOR1.71,systemthatactsviathelectinpathway.Complementacti-95%CI1.02–2.87,p=0.048).Theresultsofourstudyvationplaysasubstantialroleintherenalinjuryinherenttosuggestthatficolin-2rs7851696genepolymorphismkidneytransplantation.Inthisstudy,we
4、examinedtheinfluenceskidneyallograftfunctions,withTalleleassociationsbetweenficolin-2genepolymorphismsinexonincreasingtheriskofDGFandAR.8andkidneyallograftfunction.Thisstudycomprised270Caucasiandeceased-donorrenaltransplantrecipients.TheKeywordsDiabetesTransplantation
5、followingparameterswererecordedineachcase:delayedSingle-nucleotidepolymorphismGenePolymorphismsgraftfunction(DGF),acuterejection(AR),andchronicallograftdysfunction.AmongpatientswithDGF,weobservedasignificantlyincreasedfrequencyofrs7851696IntroductionGTandTTgenotype
6、saswellasTallele(TT?GTvsGGOR1.98,95%CI1.12–3.48,p=0.02;TvsGOR2.08,Kidneytransplantationisacommonlyusedtherapyfor95%CI1.27–3.41,p=0.005).Therewasalsoanchronickidneydiseases.Unfortunately,kidneytransplan-increasedfrequencyofrs4521835GGandTGgenotypesastationisassociated
7、withseveralcomplicationsaffectingwellasGalleles;however,thesedifferenceswereonthegraftfunction.Especiallyprevalentamongthesecompli-borderlineofstatisticalsignificance(GG?TGvsTT,ORcationsaredelayedgraftfunction(DGF),acuterejection1.75,95%CI0.98–3.12,p=0.07;GvsTOR1.45,9
8、5%(AR),andchronicallograftdysfunction(CAD).GraftCI1.00–2.09,p=0.050).Inaddition,weobservedantransplantationinducesseveralchangesint
