Prediagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations英文资料

《Prediagnostic 25-Hydroxyvitamin D, VDR and CASR Polymorphisms, and Survival in Patients with Colorectal Cancer in Western European Populations英文资料》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、PublishedOnlineFirstJanuary25,2012;DOI:10.1158/1055-9965.EPI-11-1065CancerEpidemiology,BiomarkersResearchArticle&PreventionPrediagnostic25-HydroxyvitaminD,VDRandCASRPolymorphisms,andSurvivalinPatientswithColorectalCancerinWesternEuropeanPopulations123134,5VeronikaFe

2、dirko,ElioRiboli,AnneTjønneland,PietroFerrari,AnjaOlsen,H.BasBueno-de-Mesquita,4,6248FranzelJ.B.vanDuijnhoven€,TeresaNorat,EugeneH.J.M.Jansen,ChristinaC.Dahm,910,1110,1110,11KimOvervad,Marie-ChristineBoutron-Ruault,FrancoiseClavel-Chapelon¸,AntoineRacine,12121313An

3、nekatrinLukanova,BirgitTeucher,HeinerBoeing,KrasimiraAleksandrova,14,151416172,18AntoniaTrichopoulou,VassilikiBenetou,DimitriosTrichopoulos,SaraGrioni,PaoloVineis,1920217622SalvatorePanico,DomenicoPalli,RosarioTumino,PeterD.Siersema,PetraH.Peeters,GuriSkeie,2223,242

4、4,2526MagrittBrustad,Maria-DoloresChirlaque,AurelioBarricarte,JoseRamonQuiros,24,2728293031MariaJoseSanchez,MirenDorronsoro,CatalinaBonet,RichardPalmqvist,GoranHallmans€,323233341TimothyJ.Key,FrancescaCrowe,Kay-TeeKhaw,NickWareham,IsabelleRomieu,1221JamesMcKay,P

5、etraA.Wark,DoraRomaguera,andMazdaJenabAbstractBackground:Individualswithhigherblood25-hydroxyvitaminD[25(OH)D]levelshavealowerriskofdevelopingcolorectalcancer(CRC),buttheinfluenceof25(OH)DonmortalityafterCRCdiagnosisisunknown.Methods:Theassociationbetweenprediagnosti

6、c25(OH)DlevelsandCRC-specific(N¼444)andoverallmortality(N¼541)wasprospectivelyexaminedamong1,202participantsdiagnosedwithCRCbetween1992and2003intheEuropeanProspectiveInvestigationintoCancerandNutrition(EPIC)cohort.MultivariableCoxproportionalhazardsmodelswereusedtoca

7、lculateHRsandcorresponding95%CIsaccordingto25(OH)DquintilesandgeneticvariationwithintheVDRandCASRgenes.Potentialdietary,lifestyle,andmetaboliceffectmodifierswerealsoinvestigated.Results:Therewere541deaths,444(82%)duetoCRC.Meanfollow-upwas73months.Inmultivariableanaly

8、sis,higher25(OH)DlevelswereassociatedwithastatisticallysignificantreductioninCRC-specific(Ptrend¼0.04)andoverallmortality(Ptrend¼0.01).Parti