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1、MolecularPharmacologyFastForward.PublishedonDecember14,2015asDOI:10.1124/mol.115.101360Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.MOL#101360AGeneExpressionSignatureAssociatedWithOverallSurvivalinPatientsWithHepatocellularCar
2、cinomaSuggestsaNewTreatmentStrategyJean-PierreGillet,JesperB.Andersen,JamesP.Madigan,SudhirVarma,RachelK.Bagni,KatiePowell,WilliamE.Burgan,Chung-PuWu,AnnaMariaCalcagno,SureshV.Ambudkar,DownloadedfromSnorriS.Thorgeirsson,MichaelM.Gottesmanmolpharm.aspetjournals.orgL
3、aboratoryofCellBiology(J-P.G.,J.P.M.,C-P.W.,A.M.C.,S.V.A.,M.M.G.),andLaboratoryofExperimentalCarcinogenesis(J.B.A.,S.S.T.)CenterforCancerResearch,NationalCancerInstitute,NIH;BioinformaticsandComputationalBiosciencesBranch,OfficeofCyberInfrastructureandComputational
4、Biology,OfficeofScienceManagementandOperations,NationalInstituteofAllergyandInfectiousDiseases,NIH,Bethesda,MD(S.V.);ViralTechnologiesGroupandMolecularDetectionGroup,ProteinExpressionLaboratory,FrederickNationalLaboratoryforCancerResearch,NIH,Frederick,MD(R.K.B.,K.
5、P.,W.E.B.)atASPETJournalsonAugust7,20181MolecularPharmacologyFastForward.PublishedonDecember14,2015asDOI:10.1124/mol.115.101360Thisarticlehasnotbeencopyeditedandformatted.Thefinalversionmaydifferfromthisversion.MOL#101360Runningtitle:HCCgeneexpressionpatternsuggest
6、snewtreatmentstrategyAddresscorrespondenceto:MichaelGottesman,M.D.,LaboratoryofCellBiology,37ConventDr.,Rm.2108,Bethesda,MD20892,Phone:301-496-1530,Fax:301-402-0450,email:mgottesman@nih.govDownloadedfromNumberoftextpages:24tables:2molpharm.aspetjournals.orgfigures:
7、4references:41wordsintheAbstract:237wordsintheIntroduction:569atASPETJournalsonAugust7,2018wordsintheDiscussion:812Non-standardabbreviations:HCC,hepatocellularcarcinoma;HBV,hepatitisBvirusOS,HCV,hepatitiscvirus;overallsurvival;MDR,multidrugresistance;PEI,percutaneo
8、usethanolinjection;RFA,radiofrequencyablation;TACE,transcatheterarterialchemoembolization;TLDA,TaqManlowdensityarray2MolecularPharmacologyFastFor
