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1、SurgicalOncology21(2012)316e323ContentslistsavailableatSciVerseScienceDirectSurgicalOncologyjournalhomepage:www.elsevier.com/locate/suroncReviewEpithelialmesenchymaltransitionincolorectalcancer:Seminalroleinpromotingdiseaseprogressionandresistancetoneoadjuvanttherapya,bcdea,bc,*A
2、neelBhangu,GemmaWood,AlexMirnezami,AraDarzi,ParisTekkis,RobertGoldinaDepartmentofColorectalSurgery,TheRoyalMarsdenHospital,London,UKbDivisionofSurgery,ImperialCollege,ChelseaandWestminsterCampus,London,UKcCentreforPathology,ImperialCollege,St.Mary’sHospital,FulhamRoad,London,UKdC
3、ancerSciencesDivision,CancerResearchUKCentre,UniversityofSouthampton,Southampton,UKeAcademicSurgicalUnit,DepartmentofBiosurgeryandSurgicalTechnology,ImperialCollege,StMary’sHospital,London,UKarticleinfoabstractArticlehistory:Background:Epithelialmesenchymaltransition(EMT)maybephy
4、siologicalaspartofembryologicalAccepted22August2012development,orpathologicalaspartofcancerdevelopment.Itisoneofthekeyinitiatingeventsinthemetastaticcascade.EMThasprofoundeffectsontumourcellinvasiveness,proliferationandmotility.InKeywords:thepresentarticleweaimedtoreviewthepotent
5、ialroleofEMTasaprocesstoexplaincolorectalcancerEpithelialmesenchymaltransitionprogressionandresistancetoneoadjuvanttherapy.ColorectalcancerMethods:ExtensiveliteraturesearcheswereperformedinPubmed,EMBASEandGoogleScholardata-Rectalcancerbasestoidentifyrelevantarticlespublishedbefor
6、eMarch2012.Results:ThereisadequateevidencetosupportthecomplexupstreamsignallingalterationsneededforEMTtooccurincolorectalcancers.ChangesofEMTarelikelytobefoundatthetumourinvasivefront:thedeepest,growingtumourmargin.LossofE-cadherinatthecellmembranecauseslossofcellularintegrity,wi
7、thsubsequentmigrationofmalignantcellsandtumourbudding.Theseprocessesareassociatedwithmetastasesandrecurrenceofcolorectalcancer.ThereisearlyevidencefromalimitednumberofstudiesthatresistancetoneoadjuvanttherapyincolorectalcancerisassociatedwithchangesofEMT.However,thereisalackofsup
8、portingevidenceoriginatingfromhumancolor
