资源描述：
《Naringin attenuates acute lung injury in LPS-treated mice by inhibiting NF-kappa B pathway》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、InternationalImmunopharmacology11(2011)1606–1612ContentslistsavailableatScienceDirectInternationalImmunopharmacologyjournalhomepage:www.elsevier.com/locate/intimpNaringinattenuatesacutelunginjuryinLPS-treatedmicebyinhibitingNF-κBpathwaya,1b,1aaaa,⁎YingLiu,HaoWu,Yi-chuNi
2、e,Jia-lingChen,Wei-weiSu,Pei-boLiaGuangdongKeyLaboratoryofPlantResources,SchoolofLifeScience,SunYat-SenUniversity,Guangzhou510275,ChinabChinaPharmaceuticalUniversity,Nanjing210009,ChinaarticleinfoabstractArticlehistory:Naringinhasbeenreportedasaneffectiveanti-inflammator
3、ycompound.WepreviouslyshowedthatnaringinReceived22February2011hadantitussiveeffectonexperimentallyinducedcoughinguineapigs.However,theeffectsandmechanismofReceivedinrevisedform19May2011naringinonlipopolysaccharide(LPS)-inducedacutelunginjury(ALI)inmicearenotfullyunderst
4、ood.InthisAccepted19May2011study,ouraimwastoevaluatetheanti-inflammatoryactivitiesofnaringinonLPS-inducedALIinmiceandclarifyAvailableonline1June2011itsunderlyingmechanismsofaction.Wefoundthatinvivopretreatmentwithnaringinmarkedlydecreasedthelungwetweighttodryweightratio,
5、andledtosignificantattenuationofLPS-inducedevidentlungKeywords:Naringinhistopathologicalchanges.Meanwhile,naringinsignificantlyreducedbronchoalveolarlavagefluid(BALF)totalLipopolysaccharidecellandneutrophil(PMN)countsafterLPSchallenge.Furthermore,naringininhibitedmyelopero
6、xidase(MPO:aLungmarkerenzymeofneutrophilgranule)andinduciblenitricoxidesynthase(iNOS)activitiesinlungtissueandAnti-inflammationalleviatedLPS-inducedtumorneurosisfactor-α(TNF-α)secretioninBALFinadose-dependentmanner.NF-κBAdditionally,Westernblottingshowedthatnaringineffici
7、entlybluntNF-κBactivationbyinhibitingthedegradationofIB-αandthetranslocationofp65.Takentogether,theseresultssuggestthatnaringinshowsanti-inflammatoryeffectsthroughinhibitinglungedema,MPOandiNOSactivities,TNF-αsecretionandpulmonaryneutrophilinfiltrationbyblockadeofNF-κBinL
8、PS-inducedALI.©2011ElsevierB.V.Allrightsreserved.1.IntroductionNaringinisakindofbioflavonoidderivedfromgrapefru
