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1、Chungetal.Nutrition&Metabolism2014,11:2http://www.nutritionandmetabolism.com/content/11/1/2RESEARCHOpenAccessOleanolicacidattenuatesrenalfibrosisinmicewithunilateralureteralobstructionviafacilitatingnucleartranslocationofNrf21,21,311,31,25SungjinChung,
2、HyeEunYoon,SooJeongKim,SungJunKim,EunSilKoh,YuAhHong,1,41,21,3*CheolWheePark,YoonSikChangandSeokJoonShinAbstractBackground:Renalinterstitialfibrosisisacommonfinalpathologicalprocessintheprogressionofkidneydisease.Thisisprimarilyduetooxidativestress,whi
3、chcontributestorenalinflammationandfibrosis.Nuclearfactor-erythroid-2-relatedfactor2(Nrf2)isknowntocoordinateinductionofgenesthatencodeantioxidantenzymes.Weinvestigatedtheeffectsofoleanolicacid,aknownNrf2activator,onoxidativestress-inducedrenalinflamma
4、tionandfibrosis.Methods:Onedaybeforeunilateralureteralobstruction(UUO)performedinC57BL/6mice,oleanolicacidtreatmentwasinitiatedandwascontinueduntil3and7daysafterUUO.Renalinflammationandfibrosis,markersofoxidativestress,andchangesinNrf2expressionweresub
5、sequentlyevaluated.Results:IntheobstructedkidneysofUUOmice,oleanolicacidsignificantlyattenuatedUUO-inducedcollagendepositionandfibrosisonday7.Additionally,significantlylessinflammatorycellinfiltration,alowerratioofBaxtoBcl-2expression,andfewerapoptotic
6、cellsonTUNELstainingwereobservedintheobstructedkidneysofoleanolicacid-treatedmice.OleanolicacidincreasedtheexpressionofnuclearNrf2,hemeoxygenase-1,NAD(P)H:quinoneoxidoreductase1andheatshockprotein70,anddecreasedlipidperoxidationintheobstructedkidneyofU
7、UOmice.TherewerenochangesintheexpressionoftotalNrf2andKelch-likeECH-associatedprotein1,indicatingthatoleanolicacidenhancednucleartranslocationofNrf2.Conclusions:Theseresultssuggestthatoleanolicacidmayexertbeneficialeffectsonrenalfibrosisbyincreasingnuc
8、leartranslocationofNrf2andsubsequentlyreducingrenaloxidativestress.Backgroundthereareseveralreportsthatoxidativestressplaysasig-Tubulointerstitialfibrosisisthefinalcommonpatho-nificantroleinrenaldamageinobstructedkidneys[3-5].logicalfea
