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1、SPECIALFOCUSyRNAvaccinesReviewmRNA-baseddendriticcellvaccinesExpertRev.VaccinesEarlyonline,1–16(2014)Daphne´Benteyn1,Cancerimmunotherapyhasbeenproposedasapowerfultreatmentmodality.ActiveCarloHeirman1,immunotherapyaspirestostimulatethepatient’simmunesystem,particularlyTcells.These1cellscanrecognize
2、andkillcancercellsandcanformanimmunologicalmemory.DendriticAudeBonehill,1,2cells(DCs)aretheprofessionalantigen-presentingcellsofourimmunesystem.TheytakeupKrisThielemansand1andprocessantigenstopresentthemtoTcells.Consequently,DCshavebeeninvestigatedKarineBreckpot*asameanstostimulatecancer-specificT
3、-cellresponses.AnefficientstrategytoprogramDCs1LaboratoryofMolecularandCellularistheuseofmRNA,awell-definedandsafemoleculethatcanbeeasilygeneratedathighTherapy,DepartmentofBiomedicalpurity.Importantly,vaccinesconsistingofmRNA-modifiedDCsshowedpromisingresultsinSciences,VrijeUniversiteitBrussel,Laa
4、rbeeklaan103/E,1090Jette,clinicaltrials.Therefore,wewillintroducecancerimmunotherapyandDCsandgiveadetailedBelgiumoverviewontheapplicationofmRNAtogeneratecancer-fightingDCvaccines.2DendriticCellBank,VrijeUniversiteitBrussel,Jette,BelgiumKEYWORDS:cancer•cytotoxicTcell•dendriticcell•mRNA•tumorantigen
5、*Authorofcorrespondence:Tel.:+3224774565Fax:+3224774568Thenumberofpatientssufferingfromcancercancercells,theseTcellscanformanimmuno-kbreckpo@vub.ac.beisrisingfasterthanever[1].Althoughcurrentlogicalmemoryandassuchprovideafirstlinetreatmentmodalitiesincludingchemotherapy,defenseagainstrecurringcanc
6、ercells.radiationtherapyandsurgeryhavevastlyIncontrasttoactiveimmunotherapy,passiveimprovedtheoutcomeofcancer,theireffec-immunotherapyprovides‘ready-to-use’toolstivenessislimitedinalargenumberoftoenhanceanti-tumorimmuneresponses.Forpersonaluseonly.patients.Therefore,othertreatmentstrategiesAlthoug
7、hthecurrentreviewfocusesonDCsforareunderdevelopment,includingcancercancerimmunotherapy,twoformsofpassiveimmunotherapy[2].Cancerimmunotherapyimmunotherapydeserveattentioninlightofaspirestoinduceorenhanceexistingtu
