Dendro-dendritic cholinergic excitation controls dendritic spike initiation in retinal ganglion cells.[2017][Nat Commun][10.1038ncomms15683]

《Dendro-dendritic cholinergic excitation controls dendritic spike initiation in retinal ganglion cells.[2017][Nat Commun][10.1038ncomms15683]》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、ARTICLEReceived28Jun2016

2、Accepted12Apr2017

3、Published7Jun2017DOI:10.1038/ncomms15683OPENDendro-dendriticcholinergicexcitationcontrolsdendriticspikeinitiationinretinalganglioncellsA.Brombas1,*,S.Kalita-deCroft1,*,E.J.Cooper-Williams1&S.R.Williams1Theretinaprocesses

4、visualimagestocomputefeaturessuchasthedirectionofimagemotion.Starburstamacrinecells(SACs),axonlessfeed-forwardinterneurons,areessentialcomponentsoftheretinaldirection-selectivecircuitry.RecentworkhashighlightedthatSAC-mediateddendro-dendriticinhibitioncontrolsthe

5、actionpotentialoutputofdirection-selectiveganglioncells(DSGCs)byvetoingdendriticspikeinitiation.However,SACsco-releaseGABAandtheexcitatoryneurotransmitteracetylcholineatdendriticsites.Hereweusedirectdendriticrecordingstoshowthatpreferreddirectionlightstimulievoke

6、SAC-mediatedacetylcholinerelease,whichpowerfullycontrolsthestimulussensitivity,receptivefieldsizeandactionpotentialoutputofON-DSGCsbyactingasanexcitatorydrivefortheinitiationofdendriticspikes.Consistentwiththis,pairedrecordingsrevealthattheactivationofsingleON-SAC

7、sdrovedendriticspikegeneration,becauseofpredominatecholinergicexcitationreceivedonthepreferredsideofON-DSGCs.Thus,dendro-dendriticreleaseofneurotransmittersfromSACsbi-directionallygatedendriticspikeinitiationtocontrolthedirectionallyselectiveactionpotentialoutput

8、ofretinalganglioncells.1QueenslandBrainInstitute,TheUniversityofQueensland,Brisbane,QueenslandQLD4072,Australia.*Theseauthorscontributedequallytothiswork.CorrespondenceandrequestsformaterialsshouldbeaddressedtoS.R.W.(email:srw@uq.edu.au).NATURECOMMUNICATIONS

9、8:15

10、683

11、DOI:10.1038/ncomms15683

12、www.nature.com/naturecommunications1ARTICLENATURECOMMUNICATIONS

13、DOI:10.1038/ncomms15683healgorithmsunderlyingneuronalcircuit-basedsitesofSACs16,23,25–27,33–36,theseobservationssuggestthatSAC-computationsareembeddedinnetworkconnectivity

14、,andmediatedcholinergicexcitationmayalsofunctiontocontrolTimplementedbythefunctionaloperationsofcomponentdendriticelectrogenesis.synapsesandneurons.Theretinapr