Cancer cell detection in tissue sections using AFM

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1、ArchivesofBiochemistryandBiophysics518(2012)151–156ContentslistsavailableatSciVerseScienceDirectArchivesofBiochemistryandBiophysicsjournalhomepage:www.elsevier.com/locate/yabbiCancercelldetectionintissuesectionsusingAFMa,⇑babcMałgorzataLekka,DorotaGil,KatarzynaPogoda,J

2、oannaDulin´ska-Litewka,RobertJach,aaaaJustynaGostek,OlesyaKlymenko,SzymonPrauzner-Bechcicki,ZbigniewStachura,adbJoannaWiltowska-Zuber,KrzysztofOkon´,PiotrLaidleraTheHenrykNiewodniczan´skiInstituteofNuclearPhysics,PolishAcademyofSciences,Radzikowskiego152,31-342Kraków,P

3、olandbChairofMedicalBiochemistry,JagiellonianUniversityMedicalCollege,Kopernika7,31-034Kraków,PolandcChairofGynaecologyandObsterics,DepartmentofGynaecologicalOncology,JagiellonianUniversityMedicalCollege,Kopernika23,31-501Kraków,PolanddChairofPathomorphology,Jagielloni

4、anUniversityMedicalCollege,Grzegórzecka16,31-531Kraków,PolandarticleinfoabstractArticlehistory:Currently,cancerdiagnosisreliesmostlyonmorphologicalexaminationofexfoliated,aspiratedcellsorReceived4November2011surgicallyremovedtissue.Aslongasstandarddiagnosisisconcerned,

5、thisclassicalapproachseemstoandinrevisedform16December2011besatisfactory.Intherecentyears,cancerprogressionhasbeenshowntobeaccompaniedbyalterationsAvailableonline23December2011inmechanicalpropertiesofcells.Thisoffersthedetectionofotherwiseunnoticedcancercelldisregarded

6、byhistologicalanalysisduetoinsignificantmanifestations.Oneoftechniques,sensitivetochangesinKeywords:mechanicalproperties,istheatomicforcemicroscopy,whichdetectscancercellsthroughtheirelasticSinglecellbiomechanicsproperties.Suchmeasurementswereappliedtotissuesectionscoll

7、ectedfrompatientssufferingfromTissuestiffnessvariouscancers.Despiteofheterogeneityandcomplexityofcancercellsections,theuseoftheYoung’sAtomicforcemicroscopyCancermodulusasanindicatorofcellelasticityallowfordetectionofcancercellsintissueslices.Ó2011ElsevierInc.Allrightsr

8、eserved.Introductionofcells[3,4].Thecorrelationbetweenthecellabilitytodeformanddifferentdiseaseshasbeenknownforalongt