Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf

Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf

ID:34559069

大小:1.67 MB

页数:11页

时间:2019-03-07

Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf_第1页
Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf_第2页
Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf_第3页
Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf_第4页
Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf_第5页
资源描述:

《Ca2 , cancer cell migration, SOCE, Cancer cell, 2009.pdf》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库

1、CancerCellArticleOrai1andSTIM1AreCriticalforBreastTumorCellMigrationandMetastasisShengyuYang,1J.JillianZhang,1andXin-YunHuang1,*1DepartmentofPhysiology,WeillMedicalCollegeofCornellUniversity,NewYork,NY10065,USA*Correspondence:xyhuang@med.cornell.eduDOI10.1016/j.ccr.2008.12.

2、019SUMMARYTumormetastasisistheprimarycauseofdeathofcancerpatients.Understandingthemolecularmechanismsunderlyingtumormetastasiswillprovidepotentialdrugtargets.WereportherethatOrai1andSTIM1,bothofwhichareinvolvedinstore-operatedcalciumentry,areessentialforbreasttumorcellmigra

3、tioninvitroandtumormetastasisinmice.ReductionofOrai1orSTIM1byRNAinterferenceinhighlymetastatichumanbreastcancercellsortreatmentwithapharmacologicalinhibitorofstore-operatedcalciumchannelsdecreasedtumormetastasisinanimalmodels.OurdatademonstratearoleforOrai1andSTIM1intumorme

4、tastasisandsuggeststore-operatedcalciumentrychannelsaspotentialcancertherapeutictargets.INTRODUCTIONtumorcellsintolymphaticandbloodvesselsaswellastheextravasationoftumorcellsintothesecondaryorgans(MareelDespitethesignificantimprovementinbothdiagnosticandandLeroy,2003;Steeg,2

5、006).Cellmigrationisasequentialtherapeuticmodalitiesforthetreatmentofcancerpatients,andinterrelatedmultistepprocessinvolvingtheformationofmetastasisstillrepresentsthemajorcauseofmortality,beinglamellipodia/membraneprotrusionsatthefrontedge,cyclesofresponsiblefor90%ofallcan

6、cerdeaths(Christofori,2006;Ha-adhesionanddetachment,cellbodycontraction,andtailretrac-nahanandWeinberg,2000).Metastasisisthemultistepprocesstion(Ridleyetal.,2003).Focaladhesionturnoverplaysapivotalwhereinaprimarytumorspreadsfromitsinitialsitetosecondaryroleincellmigration.S

7、mall,nascentfocaladhesionsatthetissues/organs(Fidler,2003;Weiss,2000).Todisseminatefromleadingedgeserveastractionpointsfortheforcesthatmoveprimarytumorsandestablishsecondarytumors,cancercellsthecellbodyforward.Ontheotherhand,disassemblyoffocalmustsucceedinmigration/invasion

8、,infiltrationintocirculation,adhesionsattherearallowstheretractionoftherearandnetsu

当前文档最多预览五页,下载文档查看全文

此文档下载收益归作者所有

当前文档最多预览五页,下载文档查看全文
温馨提示:
1. 部分包含数学公式或PPT动画的文件,查看预览时可能会显示错乱或异常,文件下载后无此问题,请放心下载。
2. 本文档由用户上传,版权归属用户,天天文库负责整理代发布。如果您对本文档版权有争议请及时联系客服。
3. 下载前请仔细阅读文档内容,确认文档内容符合您的需求后进行下载,若出现内容与标题不符可向本站投诉处理。
4. 下载文档时可能由于网络波动等原因无法下载或下载错误,付费完成后未能成功下载的用户请联系客服处理。