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1、©TheAmericanSocietyofGene&CellTherapyoriginalarticleoriginalarticleMTOpenmiR197/CKS1B/STAT3-mediatedPD-L1NetworkinNSCLC©TheAmericanSocietyofGene&CellTherapyTheClinicalRelevanceofthemiR-197/CKS1B/STAT3-mediatedPD-L1NetworkinChemoresistantNon-small-cellLungCancerYuFujita1,2,Shi
2、gehiroYagishita3,KeitaroHagiwara1,YusukeYoshioka1,NobuyoshiKosaka1,FumitakaTakeshita1,TomohiroFujiwara1,KojiTsuta4,HiroshiNokihara3,TomohideTamura3,HisaoAsamura5,MakotoKawaishi2,KazuyoshiKuwano2andTakahiroOchiya11DivisionofMolecularandCellularMedicine,NationalCancerCenterRese
3、archInstitute,Tokyo,Japan;2DivisionofRespiratoryDiseases,DepartmentofInternalMedicine,JikeiUniversitySchoolofMedicine,Tokyo,Japan;3DepartmentofThoracicOncology,NationalCancerCenterHospital,Tokyo,Japan;4DepartmentofPathology,NationalCancerCenterHospital,Tokyo,Japan;5Department
4、ofThoracicSurgery,NationalCancerCenterHospital,Tokyo,JapanProgrammedcelldeathligand-1(PD-L1)hasrecentlydevelopmentofnoveltargetedtherapies,theprognosisoflunggainedconsiderableattentionforitsroleintumorcancerremainspoorduetodrugresistanceandtumorrecurrence.immuneescape.Here,we
5、identifyamiR-197/CKS1B/UnderstandingthecriticalmolecularmechanismsunderlyingtheSTAT3-mediatedPD-L1networkinchemoresistantdevelopmentofchemoresistanceinNSCLCisanimportantissuenon-small-celllungcancer(NSCLC),independentoffordevelopingnovelandeffectivetherapeuticstrategies.immun
6、oinhibitorysignals.miR-197isdownregulatedMicroRNAs(miRNAs),afamilyofshortendogenousnoncod-inplatinum-resistantNSCLCspecimens,resultinginingRNAs,playcriticalrolesincellgrowth,differentiation,andthepromotionofchemoresistance,tumorigenicity,thedevelopmentofvarioussolidandhematol
7、ogicalmalignan-cies.2Recently,miRNAshaveemergedinNSCLCasbothdiag-andpulmonarymetastasisinvitroandinvivo.Mech-nosticandprognosticbiomarkers.3ThesefindingssuggestthatanisticinvestigationsrevealthatamiR-197-mediatedCKS1B/STAT3axisexertstumorprogressionregulatedmiRNAsareapromisin
8、gtechnologyforthedevelopmentofther-byvariousoncogenicgenes(Bcl-2,c-M
