Activation of Wnt_β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.

Activation of Wnt_β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging.

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时间:2019-08-06

Activation of Wnt_β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging._第1页
Activation of Wnt_β-catenin signaling by lithium chloride attenuates d-galactose-induced neurodegeneration in the auditory cortex of a rat model of aging._第2页
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1、ReceivedDate:10-Dec-2016RevisedDate:27-Feb-2017AcceptedDate:06-Mar-2017Articletype:ResearchArticleActivationofWnt/β-cateninsignalingbylithiumchlorideattenuatesD-galactose-inducedneurodegenerationintheauditorycortexofaratmodelofaging1,*1,*11111Ming-YuXia

2、,Xue-YanZhao,Qi-LinHuang,Hai-YingSun,ChenSun,JieYuan,ChangHe,Yu1321,3Sun,XiangHuang,WenKongandWei-JiaKongArticle1DepartmentofOtolaryngology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan,Hubeiprovince,P.R.China2Departm

3、entofEndocrinology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan,Hubeiprovince,P.R.China3InstituteofOtorhinolaryngology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Wuhan,Hubeiprovince,P

4、.R.China*Theseauthorscontributedequallytothiswork.Correspondingauthor:Wei-JiaKongInstitute:DepartmentofOtorhinolaryngology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnology,Address:JiefangAvenue1277,Wuhan430022,ChinaFax:+862785

5、776343Tel:+8613995569997E-mail:entwjkong@hust.edu.cnThisarticlehasbeenacceptedforpublicationandundergonefullpeerreviewbuthasnotbeenthroughthecopyediting,typesetting,paginationandproofreadingprocess,whichmayleadtodifferencesbetweenthisversionandtheVersio

6、nofRecord.Pleasecitethisarticleasdoi:10.1002/2211-5463.12220FEBSOpenBio(2017)©2017TheAuthors.PublishedbyFEBSPressandJohnWiley&SonsLtd.ThisisanopenaccessarticleunderthetermsoftheCreativeCommonsAttributionLicense,Acceptedwhichpermitsuse,distributionandrep

7、roductioninanymedium,providedtheoriginalworkisproperlycited.WenKongInstitute:DepartmentofEndocrinology,UnionHospital,TongjiMedicalCollege,HuazhongUniversityofScienceandTechnologyAddress:JiefangAvenue1277,Wuhan430022,ChinaFax:+862785776343Tel:+8613971363

8、630E-mail:wenly-kong@163.comAbbreviations:D-galD-galactoseLiclLithiumchlorideAHLagerelatedhearinglossGSK3βglycogensynthasekinase3βTCF/LEFT-cellfactor/lymphoidenhancer-bindingfactorBmi1BlymphomaMo-MLVinsertionregion1CyclinD1cellcy

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