资源描述：
《Osteoblastic Metastasis on Vertebral Bone Quality in a New Rat Model》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、EvaluatingtheEffectsofMixedOsteolytic/OsteoblasticMetastasisonVertebralBoneQualityinaNewRatModel112131LisaWise-Milestone,MargareteK.Akens,ThomasJ.Rosol,Seyed-ParsaHojjat,MarcD.Grynpas,CariM.Whyne1OrthopaedicBiomechanicsLaboratory,SunnybrookResearchInstitute,UB-19,2075BayviewAvenue,To
2、ronto,Ontario,CanadaM4N3M5,23DepartmentofVeterinaryBiosciences,TheOhioStateUniversity,307GossLab,1925CoffeyRoad,Columbus,Ohio,SamuelLunenfeldResearchInstitute,MountSinaiHospital,600UniversityAvenue,Toronto,Ontario,CanadaM5G1X5Received23June2011;accepted6October2011Publishedonline24Oc
3、tober2011inWileyOnlineLibrary(wileyonlinelibrary.com).DOI10.1002/jor.21577ABSTRACT:Spinalmetastasesoftenshowmixedareasofenhanced(osteoblastic)bonegrowthadjacenttoareasofthinning(osteolytic)bone.Thisstudyaimstoquantitativelycharacterizebonequalityandtumorburdenwithinanewratmodelofmixe
4、dosteolytic/osteoblasticspinalmetastases.Mixedvertebralmetastaseswereanalyzedinnuderats21-dayspostintracardiacinjectionofAce-1canineprostatecancercells.Vertebralmicro-architecturewasassessedinmCTimages.Histologicprocessingquantifiedtumorburden(PTHrP),osteoclastactivity(TRAP),andosteoi
5、dformation(Goldner’sTrichrome)in½ofallsamples.Remainingsamplesweremechan-icallytestedtofailureincompression.Metastaticallyinvolvedvertebraeexhibitedextremeosteolysis,evidentthroughanincreaseinosteoclastsleadingtosignificantlyreducedtrabecularbonevolume.Metastaticallyinvolvedvertebraea
6、lsoexhibitedincreasedosteoidcharacteristicofosteoblasticlesions.Whilemechanicalpropertiesintumor-bearingvertebraewerenotsignificantlydecreasedcomparedtocontrols,astrongcorrelationwasfoundbetweentrabecularvolumetricBMDandultimateforce.ThehighlyaggressiveAce-1skeletalmetastasesdemonstra
7、tedpredominantosteolysiswithsomeareasofimmature,newosteoblasticboneformation.Bonequalityresultingfromtheselesionsconsistedofdecreasedstructuralproperties,butwithoutasignificantimpactonmechanicalintegrity.ß2011OrthopaedicResearchSociety.PublishedbyWileyPeriodicals,Inc.JOrthopRes30:817–
8、823,2012Keyw
