Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model.

《Lutein attenuates oxidative stress markers and ameliorates glucose homeostasis through polyol pathway in heart and kidney of STZ-induced hyperglycemic rat model.》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、EurJNutrDOI10.1007/s00394-016-1283-0ORIGINALCONTRIBUTIONLuteinattenuatesoxidativestressmarkersandamelioratesglucosehomeostasisthroughpolyolpathwayinheartandkidneyofSTZ‑inducedhyperglycemicratmodelGurunathanSharavana1·G.S.Joseph2·VallikannanBaskaran1Received:20April2

2、016/Accepted:25July2016©Springer-VerlagBerlinHeidelberg2016Abstract(81,18and92%)inserum,heartandkidney,respectively.PurposeLutein’sroleonchronichyperglycemia-inducedAlteredantioxidantenzymeactivitiessuchassuperoxideoxidativestressandassociatedglucosehomeostasisinhea

3、rtdismutase,catalase,glutathioneperoxidase,glutathioneandkidneyislimited.Purposeofthestudyistoinvestigatereductaseandglutathionetransferasewerealsoaffectedintheeffectofluteinoncardiacandrenalpolyolpathwayserum,heartandkidneyoflutein-feddiabeticgroup.enzymesandoxidat

4、ivestressmarkersunderhyperglyce-ConclusionLuteinpreventedcardiacandrenalinjuryinmia-inducedoxidativestressconditionusingstreptozotocinSTZ-inducedhyperglycemicratsduetopotentialamelio-(STZ)-injectedratmodel.rationofalteredactivitiesinpolyolpathwayandoxidativeMethodsS

5、TZ-inducedhyperglycemic(fastingbloodglu-stressmarkers.cose≥11mM)maleWistarratsweredividedintotwogroups(n=11/group).Group1receivedmicellarluteinKeywordsDiabetes·Lutein·Nephropathy·(39nmol/day/rat)andgroup2(negativecontrol)receivedPolyolpathway·Oxidativestressmicellew

6、ithoutluteinfor8weeks.Aseparategroup(noSTZinjected)servedasapositivecontrol(n=11/group).Oralglucosetolerancetest(OGTT),biweeklyurineglu-Introductioncoseandactivitiesofaldosereductase(AR)andsorbitoldehydrogenase(SDH)enzymeswereassessed.ActivitiesDiabetesisasyndromech

7、aracterizedbyhyperglycemiaofantioxidantenzymesandantioxidantlevelwerealsoduetoinsulinresistanceornon-secretionorboth.Chronicevaluated.hyperglycemiaimpairsglucosemetabolismanddevel-ResultsLutein-administeredhyperglycemicratsshowedopssecondarycomplicationsofdiabetes[1

8、].UndersuchbetterglucosetoleranceasevidencedwithOGTTandconditions,tomaintainglucosehomeostasis,metabolismbiweeklyurineglucosewhencomparedt