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1、JPediatr. 2010May;156(5):766-70,770.e1.doi:10.1016/j.jpeds.2009.10.043.Epub2009Dec29.Bacterialovergrowthandmethaneproductioninchildrenwithencopresis.LeibyA, MehtaD, GopalareddyV, Jackson-WalkerS, HorvathK.SourceDivisionofPediatricGastroenterologyandNutrition,AlfredI.du
2、PontHospitalforChildren,Wilmington,DE19803,USA.AbstractOBJECTIVES:Toassesstheprevalenceofsmallintestinalbacterialovergrowth(SIBO)andmethaneproductioninchildrenwithencopresis.STUDYDESIGN:Radiographicfecalimpaction(FI)scoreswereassessedinchildrenwithsecondary,retentiveen
3、copresisandcomparedwiththebreathtestresults.Breathtestswithhypoosmoticlactulosesolutionwereperformedinboththestudypatients(n=50)andgastrointestinalcontrolsubjects(n=39)groups.RESULTS:TheFIscoresweresignificantlyhigherinthepatientswithencopresiswhoweremethaneproducers(P
4、<.01).SIBOwasdiagnosedin21of50(42%)patientswithencopresisand9of39(23%)ofcontrolsubjects(P=.06).Methanewasproducedin56%ofthepatientswithencopresisversus23.1%ofthecontrolsubjectsinthegastrointestinalgroup(P<.01).Fastingmethanelevelwaselevatedin48%versus10.3%,respectively
5、(P<.01).CONCLUSIONS:ChildrenwithFIandencopresishadahigherprevalenceofSIBO,elevatedbasalmethanelevels,andhighermethaneproduction.Methaneproductionwasassociatedwithmoreseverecolonicimpaction.Furtherstudyisneededtodeterminewhethermethaneproductionisaprimaryorsecondaryfact
6、orinthepathogenesisofSIBOandencopresis.References 1.DiLorenzo C. ChildhoodFunctionalGastrointestinalDisorders:Child/Adolescent. In: Drossman DAeditors. RomeIII:TheFunctionalGastrointestinalDisorders. McLean,Virginia:DegnonAssociates,Inc; 2006;p. 723–7772.Voskuijl WP,H
7、eijmans J,Heijmans HS,Taminiau JA,Benninga MA. UseofRomeIIcriteriainchildhooddefecationdisorders:applicabilityinclinicalandresearchpractice. JPediatr. 2004;145:213–217·Abstract·FullText· Full-TextPDF(128KB) ·CrossRef3.Loening-Baucke V. Encopresis. CurrOpinPediatr. 2002
8、;14:570–575·MEDLINE·CrossRef4.Gutiérrez C,Marco A,Nogales A,Tebar R. Totalandsegmentalcolonictransittimeandanorectalm
